Lack of resistance to Schistosoma japonicum in mice immunized with irradiated S. mansoni cercariae

Transactions of the Royal Society of Tropical Medicine and Hygiene
A W CheeverA Sher

Abstract

Mice immunized with irradiated Schistosoma mansoni cercariae were resistant to challenge with S. mansoni cercariae (mean resistance 53%) but not to challenge with S. japonicum cercariae (mean resistance -5%). Furthermore, the antibodies induced by vaccination with irradiated S. mansoni cercariae were more reactive with S. mansoni than with S. japonicum schistosomula. These results support the concept that the resistance induced by vaccination with irradiated cercariae is immunologically specific.

References

Jan 1, 1978·The American Journal of Tropical Medicine and Hygiene·P MinardK D Murrell
Feb 1, 1974·Experimental Parasitology·D G Colley, S K Wikel
Jul 1, 1967·The American Journal of Tropical Medicine and Hygiene·R H Duvall, W B DeWitt
Feb 1, 1983·Experimental Parasitology·D A Dean

Citations

Feb 1, 1987·International Journal for Parasitology·S R Smithers
Jan 1, 1985·Transactions of the Royal Society of Tropical Medicine and Hygiene·N A MoloneyG Webbe
Jan 1, 1986·Transactions of the Royal Society of Tropical Medicine and Hygiene·A J SimpsonS R Smithers
Apr 1, 1995·Molecular and Biochemical Parasitology·M C HugginsN A Moloney
Jun 1, 1985·Parasitology·A J SimpsonS R Smithers
Oct 1, 1987·Parasitology·C KellyS R Smithers

Related Concepts

Metazoa
Antibody Specificity
Variolation
Mice, Inbred C57BL
Schistosoma japonicum
Schistosoma mansoni
Katayama Fever
Mouse, Swiss

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Antibody Specificity

Antibodies produced by B cells are highly specific for antigen as a result of random gene recombination and somatic hypermutation and affinity maturation. As the main effector of the humoral immune system, antibodies can neutralize foreign cells. Find the latest research on antibody specificity here.