Lack of respiratory and ocular effects following acute propylene glycol exposure in healthy humans

Inhalation Toxicology
Pamela DaltonMarcy Banton

Abstract

Propylene glycol (PG) is a widely used solvent, chemical intermediate and carrier substance for foods, pharmaceutical and cosmetic products. Professional and occupational exposure to PG aerosol and vapor may occur from theatrical smoke generators and during application of deicing products to airplanes. While PG is considered to have low toxicity, the results of one study suggested that brief (1-min) exposure to PG mist elicited ocular and respiratory effects in humans. Because the high concentrations and brief exposure duration in that study were not representative of most occupational exposures, a controlled experimental exposure study was conducted to clarify or confirm the earlier findings. Ten males and 10 females were exposed to PG aerosol for 4 hrs at 20 and 100 mg/m3 and 30 min at 200 mg/m3. Total PG exposure concentrations (droplets plus gas phase) were 95.6, 442.4 and 871 mg/m3 for the three conditions, respectively. Participants rode a stationary bicycle to simulate physical effort at regular intervals during exposure. Objective measures evaluated in this study included ocular irritation via eye blink task and eye photography and pulmonary function via spirometry, while subjective measures included health symptoms rat...Continue Reading

References

Jun 1, 1975·Physiology & Behavior·R L Doty
Sep 1, 1989·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R L SuberC R Coggins
Jan 1, 1997·International Archives of Occupational and Environmental Health·P DaltonH J Lawley
Jan 5, 1999·American Journal of Respiratory and Critical Care Medicine·J L HankinsonK B Fedan
Sep 14, 2001·Occupational and Environmental Medicine·G WieslanderT Lindgren
Sep 6, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R E OpiekunP Dalton
Apr 14, 2005·American Journal of Industrial Medicine·Sunil VarugheseSusan M Kennedy
Nov 3, 2005·The European Respiratory Journal·R PellegrinoJ Wanger
May 26, 2007·Investigative Ophthalmology & Visual Science·Cintia S De PaivaStephen C Pflugfelder
Jun 16, 2010·International Archives of Occupational and Environmental Health·Gunilla Wieslander, Dan Norbäck

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Citations

Feb 15, 2019·Insects·Francisco Díaz-FleischerTrevor Williams
Jan 4, 2020·Journal of Medical Internet Research·My HuaPrue Talbot
Oct 2, 2019·BMJ : British Medical Journal·Jeffrey E GottsRobert Tarran
Nov 15, 2021·The Science of the Total Environment·Myriam BorgattaNancy B Hopf

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