Lack of robust neurologic benefits with simvastatin or atorvastatin treatment after acute thoracic spinal cord contusion injury

Experimental Neurology
Cody MannBrian K Kwon

Abstract

Although much progress has been made in the clinical care of patients with acute spinal cord injuries, there are no reliably effective treatments, which minimize secondary damage and improve neurologic outcome. The time and expense needed to establish de novo pharmacologic or biologic therapies for acute SCI has encouraged the development of neuroprotective treatments based on drugs that are already in clinical use and, therefore, have the advantage of a well-characterized safety and pharmacokinetic profile in humans. Statins are the most commonly prescribed class of lipid-lowering drugs, and recently, it has been recognized that statins also have powerful immunomodulatory and anti-inflammatory effects. This paper describes a series of experiments that were performed to evaluate the comparative neuroprotective effects of simvastatin and atorvastatin. We observed a promising signal of neurologic benefit with simvastatin in our first experiment, but in repeated attempts to replicate that effect in three subsequent experiments, we failed to reveal any behavioral or histologic improvements. We would conclude that simvastatin given orally or subcutaneously at doses previously reported by other investigators to be effective in differ...Continue Reading

References

Feb 1, 1995·Journal of Neurotrauma·D M BassoJ C Bresnahan
Jan 20, 1997·The Journal of Comparative Neurology·P G PopovichB T Stokes
Jul 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·M EndresJ K Liao
Oct 16, 2001·European Journal of Clinical Pharmacology·M IgelK von Bergmann
Jun 26, 2002·Proceedings of the National Academy of Sciences of the United States of America·Alfredo GorioMichael Brines
Dec 7, 2002·Stroke; a Journal of Cerebral Circulation·Matthew J McGirtDavid S Warner
Jun 14, 2003·Brain : a Journal of Neurology·Jennifer E A WellsV Wee Yong
Mar 6, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·David P StirlingWolfram Tetzlaff
Nov 9, 2004·Trends in Pharmacological Sciences·María Domercq, Carlos Matute
Dec 18, 2004·Journal of Neuroscience Research·Ravinder PannuInderjit Singh
Jan 22, 2005·Fundamental & Clinical Pharmacology·Michael Schachter
Jun 2, 2005·Neurotoxicology·Stefano BartesaghiBarbara Viviani
Apr 25, 2006·Journal of Neurotrauma·Frank P T HamersElbert A J Joosten
May 24, 2007·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Mauro CiminoLuigi Sironi

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Citations

Mar 18, 2011·Journal of Neurotrauma·Femke StreijgerWolfram Tetzlaff
Apr 21, 2010·Journal of Inflammation·Anandakumar ShunmugavelInderjit Singh
Mar 26, 2011·Journal of Biomedicine & Biotechnology·Aya NakaeTakashi Mashimo
Nov 13, 2014·International Journal of Molecular Sciences·Amelia J McFarlandAndrew K Davey
Mar 27, 2012·Journal of Cardiothoracic and Vascular Anesthesia·Jinyoung HwangSunghee Han
Nov 26, 2013·Progress in Neurobiology·Nuno A SilvaAntónio J Salgado
Aug 2, 2014·European Journal of Pharmacology·Ramazan KahveciBülent Erdoğan
Dec 28, 2017·Asian Spine Journal·Javad AghazadehSeyed Ahmad Naseri Alavi
Sep 30, 2016·Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie·Klaus Sarimski, Markus Lang
Dec 31, 2010·Current Opinion in Neurology

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