Lack of seasonal rhythms in central serotonergic function in boys with ADHD

Psychoneuroendocrinology
Kurt P SchulzJeffrey M Halperin

Abstract

This study examined seasonal variations in central 5-HT function in a relatively large sample of prepubertal boys with attention-deficit/hyperactivity disorder (ADHD). In addition, seasonal differences in central 5-HT function among aggressive and non-aggressive children in the sample were explored. Ninety-three boys with ADHD were divided into aggressive (n=54) and nonaggressive (n=39) groups based on parental responses to interviews and ratings of behavior. Central 5-HT function was assessed by measuring the prolactin response to a single 1 mg/kg oral dose of d,l-fenfluramine. The prolactin values were derived from different children over the course of eight years, but were collapsed across years and analyzed in terms of day of the year. Cosinor analysis revealed no annual, bi-annual, 3-monthly, 2-monthly, monthly, or bi-monthly rhythms in the prolactin response in the entire sample of boys with ADHD. Moreover, there was no evidence of seasonal differences in the prolactin response between the aggressive and non-aggressive subgroups. These results indicate that seasonality-related variance is not a threat to the validity of the neurochemical procedure and does not account for the inconsistencies in the studies of central 5-HT...Continue Reading

References

May 1, 1992·The British Journal of Psychiatry : the Journal of Mental Science·V O'KeaneT G Dinan
May 1, 1991·Journal of the American Academy of Child and Adolescent Psychiatry·J M Rey, A Morris-Yates
Jun 1, 1982·The American Journal of Psychiatry·G L BrownF K Goodwin
Jul 1, 1983·The American Journal of Psychiatry·R P Michael, D Zumpe
Feb 1, 1994·Psychopharmacology·R S KahnL Siever
Sep 1, 1993·Acta Psychiatrica Scandinavica·M MaesF De Meyer
Aug 1, 1996·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·P D'HondtR Desnyder
Nov 1, 1996·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·A CappielloL H Price
Dec 1, 1996·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·E F CoccaroR L Hauger
Oct 23, 1997·Journal of the American Academy of Child and Adolescent Psychiatry·J M HalperinV Sharma
Jan 1, 1996·European Psychiatry : the Journal of the Association of European Psychiatrists·M MaesR Verkerk

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Citations

May 21, 2016·Journal of Attention Disorders·Suzan W N VogelJ J Sandra Kooij

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