PMID: 2487781Jun 1, 1989Paper

Lack of specificity of Chlamydiazyme for detection of vaginal chlamydial infection in prepubertal girls

The Pediatric Infectious Disease Journal
K PorderM R Hammerschlag

Abstract

A 1-year prospective study was undertaken of 65 prepubertal girls referred for evaluation of sexual abuse or vulvovaginitis to compare Chlamydiazyme, an enzyme immunoassay (EIA), with culture for the detection of Chlamydia trachomatis i in vaginal specimens. Five (8%) of 65 patients were initially EIA-positive. On repeat sampling without intervening antibiotic treatment, 4 girls who were initially positive became negative and 1 remained persistently positive. Chlamydial cultures were negative in all patients. The patient with the persistently positive EIA also had Group A streptococcal vaginitis. We were able to demonstrate that some strains of Group A Streptococcus can cause a positive reaction with the EIA. Cross-reactions with other bacterial species are also known to occur. We therefore conclude that Chlamydiazyme is not specific for the detection of chlamydial infection in the vagina of prepubertal girls and, for medicolegal reasons, should not be used for evaluation of sexual abuse.

Citations

Jun 1, 1992·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·H HallanderB Gästrin
May 16, 2003·Seminars in Pediatric Infectious Diseases·Margaret R Hammerschlag
Dec 7, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Margaret R Hammerschlag
Jul 9, 2010·Clinical Microbiology Reviews·Margaret R Hammerschlag, Christina D Guillén
Dec 16, 1998·Sexually Transmitted Infections·M R Hammerschlag
Aug 1, 1992·Pediatric Annals·C Jenny
Jul 1, 1994·Pediatric Annals·M R Hammerschlag
Mar 1, 1996·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Margaret R. Hammerschlag
Jan 1, 1997·Immunological Investigations·M R Hammerschlag

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