Lack of support for association between the copy number variants in the FCGR locus and schizophrenia: a case control study

Neuroscience Letters
Arman ZhaoXinzhi Zhao

Abstract

The missing heritability of polygenic schizophrenia after genome-wide association studies (GWAS) can be potentially accounted for by the fact that most dynamic multiallelic copy number variants (CNVs) overlap segmental duplications (SDs). The FCGR locus covers this category of complex CNVs and it has long been postulated to harbor variants conferring the risk of schizophrenia. However, such association remains unproven. We used a case-control design to investigate CNV-based association with the disease. Data were obtained from 598 unrelated schizophrenia patients and 959 normal controls of Han ancestry from Shanghai. A total of four copy number (CN) probes in the FCGR locus were detected using TaqMan(®) Copy Number Assay. SPSS version 16.0 was used for the statistical analyses. And the frequency distributions of target CN in FCGR locus were very similar between controls and cases, whereas the CNV frequency differed markedly among different target CN analyzed in the two cohorts. When compared with the predominant two copies per diploid genome, a distinct non-protein-coding CN deletion region containing regulatory sequences was detected by probe Hs04194069_cn. Taken together, we found no evidence of association of target CNVs in ...Continue Reading

References

May 29, 2003·Human Heredity·Linda M BrzustowiczAnne S Bassett
Dec 10, 2003·Archives of General Psychiatry·Patrick F SullivanMichael C Neale
Jul 11, 2006·American Journal of Human Genetics·Devin P LockeEvan E Eichler
Sep 26, 2006·Journal of Autoimmunity·Rael D Strous, Yehuda Shoenfeld
Jun 3, 2008·Schizophrenia Research·Rajiv TandonHenry A Nasrallah
Sep 9, 2008·Nature Genetics·Steven A McCarrollDavid Altshuler
Oct 4, 2008·Nucleic Acids Research·Kai WangMingyao Li
Feb 3, 2009·Human Molecular Genetics·George KirovMichael C O'Donovan
Jan 1, 2008·Cytogenetic and Genome Research·H Kehrer-Sawatzki, D N Cooper
Jul 17, 2009·Clinical and Experimental Immunology·S BournazosI Dransfield
Jul 31, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Xu-Jie ZhouHong Zhang
Sep 30, 2009·Molecular Psychiatry·A IngasonD M St Clair
Oct 7, 2009·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Livia VeselkaPhilip A Vernon
Nov 10, 2009·Nature Biotechnology·Derek Y Chiang, Steven A McCarroll
Dec 10, 2009·Schizophrenia Bulletin·Naomi R Wray, Peter M Visscher
Jan 6, 2010·Molecular Psychiatry·S SteinbergK Stefansson
Mar 10, 2010·Expert Reviews in Molecular Medicine·Charles Lee, Stephen W Scherer
May 5, 2010·The American Journal of Psychiatry·Anne S BassettLinda M Brzustowicz
May 19, 2010·Nature Reviews. Genetics·Evan E EichlerJoseph H Nadeau
May 29, 2010·Human Molecular Genetics·Heather A NiedererKenneth G C Smith
Jul 1, 2010·Human Molecular Genetics·Evangelos VassosCathryn M Lewis
Oct 12, 2010·Nature Genetics·Elizabeth K SpeliotesRuth J F Loos
Oct 30, 2010·Science·Peter H SudmantEvan E Eichler
Dec 15, 2010·Schizophrenia Research·Junyan LiYongyong Shi
Feb 1, 2011·Current Opinion in Genetics & Development·Simon L GirardGuy A Rouleau
Apr 21, 2011·Schizophrenia Bulletin·Yunjung KimPatrick F Sullivan
Jun 7, 2011·Annual Review of Genomics and Human Genetics·Pablo V GejmanKenneth S Kendler
Jul 12, 2011·Nature Genetics·Simon L GirardGuy A Rouleau
Aug 9, 2011·Nature Genetics·Bin XuMaria Karayiorgou
Sep 20, 2011·Nature Genetics·UNKNOWN Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium
Nov 1, 2011·Nature Genetics·Yongyong ShiLin He
Apr 30, 2015·Briefings in Functional Genomics·Eric R Gamazon, Barbara E Stranger

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Autoimmune Polyendocrinopathies

Autoimmune polyendocrinopathies, also called polyglandular autoimmune syndromes (PGASs), or polyendocrine autoimmune syndromes(PASs), are a heterogeneous group of rare diseases characterized by autoimmune activity against more than one endocrine organ, although non-endocrine organs can be affected. Discover the latest research on autoimmune polyendocrinopathies here.

Related Papers

European Archives of Psychiatry and Clinical Neuroscience
D Rujescu
American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics
Ming LiBing Su
Clinical Genetics
J L DohertyMichael J Owen
© 2021 Meta ULC. All rights reserved