PMID: 2106724Feb 1, 1990Paper

Lack of the G2m(n) allotype in IgG subclass deficiency, in IgG2 deficiency together with lack of G1m(a) and G3m(g), and in IgG3 deficiency together with lack of G1m(f) and G3m(b)

Scandinavian Journal of Immunology
V A Oxelius

Abstract

Lack of G2m(n) was demonstrated in both IgG2-deficient and IgG3-deficient Caucasian patients. Lack of G2m(n) or G2m(",") was found together with homozygosity for both G1m and G3m allotypes as the dominant finding, i.e. for IgG2-deficient patients together with G1m (f,f) and G3m(b,b), constituting the Gm(f,",b) phenotype, and for IgG3-deficient patients together with G1m(a,a) and G3m(g,g), constituting the Gm(a,",g) phenotype. The group with IgG2 deficiency and the selected patients with the Gm(f,",b) phenotype expressed characteristically very low or undetectable IgG4, significantly increased IgG3, and normal IgG1. The group with IgG3 deficiency and the selected patients with the phenotype Gm(a,",g) expressed instead normal IgG4 and nearly normal IgG2 and IgG1 levels. The lack of G2m(n) together with lack of one or the other of the alternative G1m genes and corresponding G3m genes give different IgG2 levels and different IgG subclass patterns. The frequency of G1m allotypes and corresponding G3m allotypes also deviated significantly when the IgG2 deficiency and IgG3 deficiency groups were compared with each other. Most IgG subclass-deficient patients are homozygous in the Gm system and lack genetic variants in the three IgG sub...Continue Reading

References

Jan 1, 1979·Acta paediatrica Scandinavica·V A Oxelius
Nov 1, 1970·The Journal of Clinical Investigation·W J YountH G Kunkel
Sep 17, 1970·The New England Journal of Medicine·P H SchurF S Rosen

❮ Previous
Next ❯

Citations

Jan 24, 2008·Immunologic Research·Vivi-Anne Oxelius
Apr 29, 1999·Scandinavian Journal of Immunology·V A Oxelius
Apr 29, 1999·Scandinavian Journal of Immunology·V A Oxelius
Feb 1, 1993·Scandinavian Journal of Immunology·V A Oxelius, A M Carlsson
Feb 1, 1993·Scandinavian Journal of Immunology·V A Oxelius
Oct 1, 1994·Addiction·P CampionC McGuire
May 27, 2008·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Vivi-Anne OxeliusLennart Hammarström
Dec 21, 2006·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·V-A OxeliusB Björkstén
Jun 14, 2013·PloS One·Sergey RyazantsevVladimir Zav'yalov
Feb 1, 1995·Clinical and Experimental Immunology·V A OxeliusL A Hanson
Jan 1, 1993·Scandinavian Journal of Rheumatology·V A OxeliusA M Carlsson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Scandinavian Journal of Immunology
V A Oxelius, A M Carlsson
Scandinavian Journal of Immunology
V A OxeliusK Musil
© 2021 Meta ULC. All rights reserved