Lack of the T54A polymorphism of the DAZL gene in infertile Italian patients

Molecular Human Reproduction
Lucia BartoloniCarlo Foresta

Abstract

The Thr54Ala polymorphism of the deleted-in-azoospermia-like (DAZL) protein has been associated with susceptibility to spermatogenic failure in the Taiwanese population. We used single-strand conformation polymorphism and restriction fragment analyses to investigate the presence of the A-->G transition in exon 3 of the DAZL gene in 95 infertile Italian patients. The patients had oligozoospermia or non-obstructive azoospermia with different degrees of testicular cytological picture. The allele carrying T54A polymorphism was not present in this group of patients nor in 63 controls, indicating that the frequency of this putative mutation is <1% in Italy. Since the Italian population usually shows allelic frequencies similar to the other Caucasian populations, we suggest that the T54A allele might play a role in infertility only in Taiwanese or Asiatic individuals.

Citations

Feb 12, 2005·Reproductive Biomedicine Online·Nicola Reynolds, Howard J Cooke
Jan 1, 2008·Indian Journal of Human Genetics·J PoongothaiS Manonayaki
Nov 3, 2009·Journal of Human Reproductive Sciences·Kiran Singh, Rajiva Raman
Jul 7, 2007·Archives of Andrology·Csilla Krausz, Claudia Giachini
Apr 17, 2008·Reproductive Biomedicine Online·Francesca Nuti, Csilla Krausz
Jun 30, 2006·Reproductive Toxicology·Alberto FerlinCarlo Foresta
Mar 19, 2016·Molecular Human Reproduction·Roseanne RosarioRichard A Anderson
May 30, 2006·Fertility and Sterility·Yen-Ni TengPao-Lin Kuo
Apr 2, 2017·Molecular Human Reproduction·Roseanne RosarioRichard A Anderson
May 10, 2005·Molecular Human Reproduction·G CauffmanA Van Steirteghem
Oct 30, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Roseanne RosarioRichard A Anderson
Mar 8, 2013·Biology of Reproduction·Youichi SatoAtsushi Tajima
Apr 8, 2017·Systems Biology in Reproductive Medicine·Mili Nailwal, Jenabhai B Chauhan

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