PMID: 40253May 1, 1979

Lack of tolerance development to benzodiazepines in antagonism of the pentylenetetrazol discriminative stimulus

Pharmacology, Biochemistry, and Behavior
G T ShearmanH Lal


In an operant procedure of lever pressing on FR 10 schedule of food reinforcement male hooded rats were trained to respond on a lever on one side of a food cup following a 20 mg/kg pentylenetetrazol (PTZ) injection and to respond on a lever on the alternate side following a 1 ml/kg saline injection. Upon acquisition of the PTZ-saline discrimination, diazepam and chlordiazepoxide were tested and found to antagonize the PTZ discriminative stimulus. The animals were then injected with 10 mg/kg diazepam or chlordiazepoxide for ten consecutive days. New dose-response curves obtained following this treatment indicated that tolerance did not develop to the antagonism of the PTZ discriminative stimulus by these benzodiazepines.


Jan 1, 1985·Neuroscience and Biobehavioral Reviews·S E File
Jan 1, 1985·Neuroscience and Biobehavioral Reviews·D Treit
Oct 2, 2002·Life Sciences·M B GatchHarbans Lal
Jan 1, 1990·Neuroscience and Biobehavioral Reviews·S E File


Jun 1, 1964·Journal of Pharmaceutical Sciences·S J CHILDRESS, M I GLUCKMAN

Related Concepts

Discrimination (Process of Differentiation)
Anti-Anxiety Effect
Drug Tolerance
Reinforcement Schedule
Benzodiazepines Assay

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