Lack of TP53 and FMS gene mutations in children with myelodysplastic syndrome

Cancer Genetics and Cytogenetics
Biljana JekicVera Bunjevacki

Abstract

Myelodysplastic syndromes (MDS) are rare disorders in children. Molecular mechanisms underlying MDS in children are not yet completely understood. Considering the role of FMS and TP53 gene mutations in adult MDS patients, we analyzed mutations of these genes in a cohort of 35 children with MDS. Single-strand conformation polymorphism polymerase chain reaction analysis performed on FMS codon 969 and TP53 exons 5-9 showed no mutations in the analyzed sequences. Our results suggest that molecular mechanisms of MDS evolution in children are different from those in adults.

References

Jul 5, 1991·Science·M HollsteinC C Harris
Jun 6, 1991·Nature·A J LevineC A Finlay
May 1, 1995·Leukemia Research·A BakerR A Padua
Aug 25, 2004·Cancer Genetics and Cytogenetics·Angel Martínez-RamírezJavier Benítez
Oct 12, 2004·Cancer Genetics and Cytogenetics·Biljana JekicVera Bunjevacki

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