Lack of tumour pigmentation in conjunctival melanoma is associated with light iris colour and worse prognosis

The British Journal of Ophthalmology
Niels J BrouwerMartine J Jager

Abstract

To investigate whether differences in iris colour, skin colour and tumour pigmentation are related to clinical outcome in conjunctival melanoma. Data of 70 patients with conjunctival melanoma from the Leiden University Medical Center (Leiden, The Netherlands) and 374 patients from the Wills Eye Hospital (Philadephia, USA) were reviewed. The relation between iris colour, skin colour and tumour pigmentation versus clinical parameters and outcome was investigated using univariate and multivariate regression analyses. A light iris colour (blue, grey, green) was present in 261 (59%) patients and a dark colour (hazel, brown) in 183 (41%). A low tumour pigmentation was detected in 130 (40%) and a high pigmentation in 197 (60%) patients. Low tumour pigmentation was associated with light iris colour (p=0.021) but not related to skin colour (p=0.92). In univariate analysis, neither iris nor skin colour was related to clinical outcome, while a low tumour pigmentation was related to metastasis formation (HR 2.37, p=0.004) and death (HR 2.42, p=0.020). In multivariate analysis, low tumour pigmentation was related to the development of recurrences (HR 1.63, p=0.043), metastasis formation (HR 2.48, p=0.004) and death (HR 2.60, p=0.014). Light...Continue Reading

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Citations

Aug 5, 2020·Acta Ophthalmologica·Lauge Hjorth Mikkelsen
May 18, 2019·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Niels J BrouwerMartine J Jager
Jan 1, 2021·PLoS Genetics·Katarina CisarovaCarlo Rivolta
Sep 28, 2020·Survey of Ophthalmology·Yue ZengFang Wu
May 21, 2021·Progress in Retinal and Eye Research·Niels J BrouwerMartine J Jager

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