PMID: 7540637Feb 1, 1995Paper

Lack of vascular hyporesponsiveness to the L-type calcium channel activator, Bay K 8644, in rats with cirrhosis

Journal of Hepatology
M HartlebD Lebrec

Abstract

In cirrhosis, the mechanism(s) for vascular hyporesponsiveness to vasoconstrictors such as, alpha 1-adrenoceptor agonists, vasopressin and angiotensin II, are unclear. Moreover, vascular reactivity to substances such as L-type calcium channel activators is unknown. Thus, pressor dose-response curves to vasoconstrictors [phenylephrine (an alpha 1-agonist, 0.1-500 micrograms/kg) angiotensin II (10-500 ng/kg), vasopressin (0.01-5 IU/kg), and Bay K 8644 (an L-type calcium channel activator, 0.5-50 micrograms/kg)] were obtained in normal rats and in rats with secondary biliary cirrhosis. All experiments were performed in ganglionic-blocked animals to limit the influence of cardiovascular reflexes. Doses of vasoconstrictor necessary to obtain a 40 mmHg increase in arterial pressure (D40) were calculated. Compared to normal animals, rats with cirrhosis had significantly higher D40 values for angiotensin II (171 +/- 57 vs. 344 +/- 41 ng/kg), phenylephrine (2.6 +/- 0.2 vs. 26.4 +/- 10.7 micrograms/kg) and vasopressin (73 +/- 19 vs. 401 +/- 150 mU/kg). Pressor responses to Bay K 8644 did not differ between normal rats and rats with cirrhosis (8.8 +/- 0.9 vs. 10.5 +/- 2.1 micrograms/kg). In conclusion, this study shows that cirrhosis prod...Continue Reading

References

Oct 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F Y LeeR J Groszmann
Mar 30, 1991·Lancet·P Vallance, S Moncada
Feb 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J ClàriaJ Rodés
Apr 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A J MacGilchristJ L Reid
Apr 1, 1990·The Journal of Surgical Research·J V SitzmannG B Bulkley
May 1, 1988·Canadian Journal of Physiology and Pharmacology·L M VillamedianaJ M López-Novoa
Jul 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A BomzonL M Blendis
Mar 1, 1987·The Journal of Surgical Research·D GaliA Bomzon
Jan 1, 1982·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·S KitanoK Inokuchi
Jul 1, 1980·Circulation Research·S WallensteinJ L Fleiss
Aug 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A CastroJ Rodés
Jan 28, 1993·Nature·M J Berridge
Nov 22, 1962·The New England Journal of Medicine·M L MASHFORDT C CHALMERS
Sep 1, 1963·The Journal of Clinical Investigation·C I JOHNSTON, A D JOSE

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Citations

Mar 1, 1995·Journal of Hepatology·R Moreau, D Lebrec
Aug 23, 2001·Pharmacology & Therapeutics·P W Hadoke
Jan 1, 1997·Pharmacology & Therapeutics·P W Hadoke, P C Hayes
Feb 1, 1997·Journal of Hepatology·V SafkaD Lebrec
Oct 18, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Mathieu VinkenVera Rogiers
Aug 28, 2003·Alimentary Pharmacology & Therapeutics·H Reynaert, A Geerts
Jan 1, 1997·Journal of Hepatology·J Reichen
Apr 9, 2005·World Journal of Gastroenterology : WJG·Han-Chieh LinShou-Dong Lee

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