Lacrimal gland adenocarcinoma responding to checkpoint inhibition and androgen deprivation

Oxford Medical Case Reports
Ajaz Bulbul

Abstract

Although the histologically diverse classification of salivary gland tumors can be successfully applied to the epithelial lacrimal gland neoplasms, it is not clear whether the molecular makeup differs between these two different tumor types. Adenocarcinomas have known to have driver mutations in non-small cell lung cancer, however, besides HER2 expression not much is known regarding molecular drivers in lacrimal tumors. Androgen receptor (AR) expression and deprivation combined with checkpoint inhibition (CPI) have not been described before in lacrimal gland adenocarcinoma. To our knowledge, this is the first case report describing a prolonged response to CPI and AR inhibitors.

References

Aug 12, 2009·Archives of Ophthalmology·Ezekiel WeisValerie A White
Apr 5, 2012·Acta Ophthalmologica·Sarah Linéa von HolsteinSteffen Heegaard
Apr 1, 2012·Saudi Journal of Ophthalmology : Official Journal of the Saudi Ophthalmological Society·Valerie A White
Feb 28, 2015·Case Reports in Oncological Medicine·Trevor Dennie
Jun 9, 2016·Current Opinion in Ophthalmology·Kyung In WooBita Esmaeli

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Citations

Nov 11, 2021·International Ophthalmology·Reydson Alcides de Lima-SouzaFernanda Viviane Mariano

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