Lacrimal gland extranodal marginal zone B-cell lymphoma in the presence of amyloidosis.

Orbit
Chung Shen CheanChristopher Knapp

Abstract

Amyloidosis is a protein metabolism disorder characterised by extracellular deposition of insoluble amorphous hyaline material. Orbital and ocular amyloid lesions account for only 4% of localised disease affecting the head and neck. Ocular adnexal lymphoma accounts for 1-2% of lymphoma, with lacrimal gland lymphomas being relatively uncommon. The most common form affecting the orbit is extranodal marginal zone lymphoma (EMZL) of mucosa-associated lymphoid tissue (MALT lymphoma). We report an extremely rare case of co-existent EMZL and amyloidosis of the lacrimal gland. Initial biopsy of the right lacrimal gland confirmed an EMZL with amyloid deposit, and a course of radiotherapy treatment was given. Recurrent lacrimal gland swelling developed within a year. Subsequent biopsy identified amyloidosis with scanty lymphoid tissue. To our knowledge, this is the first reported case of localised lacrimal gland amyloidosis of uncertain type with previous EMZL; the association described in this case report is not yet fully understood.

References

Feb 5, 2002·Ophthalmology·Hakan DemirciJose C Tovilla
Jun 24, 2006·American Journal of Hematology·V SanchorawalaD G Wright
Jan 27, 2007·The American Journal of Surgical Pathology·Judith A FerryNancy L Harris
Jun 5, 2007·Ophthalmology·Brian D Haas, Curtis E Margo
Jun 25, 2010·American Journal of Hematology·Gregory BrownMark Roschewski
Sep 28, 2010·American Journal of Hematology·David TelioVishal Kukreti
Oct 12, 2011·Archives of Ophthalmology·Peter RasmussenSteffen Heegaard
Aug 23, 2012·Orphanet Journal of Rare Diseases·Estelle DesportUNKNOWN Centre national de référence pour l’amylose AL et les autres maladies par dépôts d’immunoglobulines monoclonales
Nov 12, 2013·Ocular Immunology and Inflammation·Jyoti BatraGeeta K Vemuganti
Oct 16, 2015·International Ophthalmology·Eduardo R Mora-HornaGuillermo Salcedo
Aug 3, 2018·Blood Cancer Journal·Geffen KleinsternJames R Cerhan

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Citations

Jul 3, 2021·Genes·Angelo Maria MinnellaLaura Obici

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