Lacrimo-auriculo-dento-digital syndrome. Case report, review of the literature, and clinical spectrum

Journal of Orofacial Orthopedics = Fortschritte Der Kieferorthopädie : Organ/official Journal Deutsche Gesellschaft Für Kieferorthopädie
Michaela LehotayHeinrich Wehrbein

Abstract

Lacrimo-auriculo-dento-digital (LADD) syndrome, also known as Levy-Hollister syndrome, is characterized by pronounced dysplasias in various organ systems. The resulting disturbances affect primarily the lacrimal glands, the inner and outer ear, the salivary glands, and the osseous framework. Although the degree to which the different organs are involved varies considerably, dental anomalies are regularly reported. An autosomal-dominant trait has been recognized for this syndrome, but the majority of cases described in the literature concerned sporadic new mutations. We report on this unusual and relatively unknown syndrome with reference to a 13-year-old girl suffering from LADD syndrome presenting symptoms of severe xerostomia and various craniofacial malformations, hearing loss, enamel dysplasia, microdontia, and hypodontia.

Citations

Jan 27, 2010·European Archives of Paediatric Dentistry : Official Journal of the European Academy of Paediatric Dentistry·G J McKennaK Mellan
Sep 20, 2008·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Yeliz GuvenOya Aktoren
Feb 19, 2008·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Nazar Al-TalabaniSaeed A Latteef
Jan 11, 2011·Journal of Pediatric Ophthalmology and Strabismus·Faysal GokWollnik Bernd
Sep 6, 2008·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·P J De CosterA Huysseune
Nov 30, 2016·Case Reports in Dentistry·Afshin Teymoortash, Stephan Hoch
Jul 28, 2020·Molecular Genetics & Genomic Medicine·Young Hye RyuSoyoung Lee

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