Lactase persistence, milk intake, and mortality in the Danish general population: a Mendelian randomization study

European Journal of Epidemiology
Helle Kirstine Mørup BergholdtChristina Ellervik

Abstract

Meta-analyses have suggested no association between milk intake and mortality. Since only few studies have been conducted, we investigated the association between the lactase persistent genetic variant LCT-13910 C/T (rs4988235), a proxy for long-term low and high intake of milk, and mortality. We used two Danish population-based studies with self-reported intake of milk and genotyping for LCT-13910 C/T. We obtained information on all-cause and cause-specific mortality (cardiovascular and cancer) from the national Danish registries. We used multivariable adjusted Cox regression to assess the association between milk intake and mortality in 74,241 individuals, and both logistic and Cox-regression to assess the association between genetic lactase persistence and mortality in 82,964 individuals using a Mendelian randomization design. We applied per T-allele, co-dominant and dominant models. During a mean follow-up of 7 years, 9759 individuals died, 2166 from cardiovascular disease, and 2822 from cancer. Observationally, there was no association between intake of skimmed milk and all-cause or cardiovascular mortality, and we did not find any associations between intake of semi-skimmed or whole milk with all-cause or cause-specific m...Continue Reading

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Citations

Nov 30, 2019·Science·Laurence Zitvogel, Guido Kroemer
Jul 24, 2018·Current Epidemiology Reports·Brandon L PierceChenan Zhang
May 6, 2020·European Journal of Epidemiology·M Arfan IkramTrudy Voortman
Dec 14, 2021·Frontiers in Nutrition·Emily SonestedtUlrika Ericson

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