Lactate and Lactate Transporters as Key Players in the Maintenance of the Warburg Effect

Advances in Experimental Medicine and Biology
Andreia Pereira-NunesFátima Baltazar

Abstract

Reprogramming of energy metabolism is a key hallmark of cancer. Most cancer cells display a glycolytic phenotype, with increased glucose consumption and glycolysis rates, and production of lactate as the end product, independently of oxygen concentrations. This phenomenon, known as "Warburg Effect", provides several survival advantages to cancer cells and modulates the metabolism and function of neighbour cells in the tumour microenvironment. However, due to the presence of metabolic heterogeneity within a tumour, cancer cells can also display an oxidative phenotype, and corruptible cells from the microenvironment become glycolytic, cooperating with oxidative cancer cells to boost tumour growth. This phenomenon is known as "Reverse Warburg Effect". In either way, lactate is a key mediator in the metabolic crosstalk between cancer cells and the microenvironment, and lactate transporters are expressed differentially by existing cell populations, to support this crosstalk.In this review, we will focus on lactate and on lactate transporters in distinct cells of the tumour microenvironment, aiming at a better understanding of their role in the acquisition and maintenance of the direct/reverse "Warburg effect" phenotype, which modula...Continue Reading

Citations

Aug 23, 2020·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Cindy Mendes, Jacinta Serpa
Jun 26, 2020·Cancer Management and Research·Diyuan ZhouXinguo Zhu
Dec 22, 2020·Frontiers in Cell and Developmental Biology·Tianxin YeXuewu Zhang
Dec 22, 2020·The Journal of Physiology·Peter Vaupel, Gabriele Multhoff
Mar 16, 2021·Frontiers in Cellular and Infection Microbiology·Dilara Kiran, Randall J Basaraba
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marta BaczewskaPaweł Knapp
Jul 3, 2021·Cancers·Diren Beyoğlu, Jeffrey R Idle
Aug 18, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Dun NiuZhizhong Xie

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