Lactate dehydrogenase inhibition: exploring possible applications beyond cancer treatment

Future Medicinal Chemistry
Giuseppina Di StefanoLuigi Fiume

Abstract

Lactate dehydrogenase (LDH) inhibition is considered a worthwhile attempt in the development of innovative anticancer strategies. Unfortunately, in spite of the involvement of several research institutions and pharma-companies, the discovery of LDH inhibitors with drug-like properties seems a hardly resolvable challenge. While awaiting new advancements, in the present review we will examine other pathologic conditions characterized by increased glycolysis and LDH activity, which could potentially benefit from LDH inhibition. The rationale for targeting LDH activity in these contexts is the same justifying the LDH-based approach in anticancer therapy: because of the enzyme position at the end of glycolytic pathway, LDH inhibitors are not expected to hinder glucose metabolism of normal cells. Moreover, we will summarize the latest contributions in the discovery of enzyme inhibitors and try to glance over the reasons underlying the complexity of this research.

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Citations

Dec 5, 2017·Journal of Enzyme Inhibition and Medicinal Chemistry·Abdul-Malek S AltamimiRaivis Žalubovskis
Jun 22, 2017·Future Medicinal Chemistry·Qingbin CuiP Huang
May 6, 2019·BMC Pharmacology & Toxicology·Agnieszka KorgaJaroslaw Dudka
Dec 9, 2016·Open Biology·Michela FalcoClaudio Arra

Related Concepts

Anti-Inflammatory Agents
Anticonvulsants
Antineoplastic Agents
Energy Metabolism
Single Seizure
Glycolysis
Inflammation
Lactate Dehydrogenase
Neoplasm Metastasis
Malignant Neoplasms

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