Lactate dehydrogenase is not a useful marker for relapse in patients on surveillance for stage I germ cell tumours.

British Journal of Cancer
C Ackers, G J Rustin

Abstract

As part of surveillance protocols for stage I germ cell tumours, many centres routinely measure human chorionic gonadotrophin (HCG), alpha feto-protein (AFP) as well as lactate dehydrogenase (LDH). In conjunction with regular imaging and clinical examination, does routine measurement of LDH add anything to our relapse/pick up rate? Records of 494 patients at Mount Vernon Hospital who relapsed on surveillance between 1985 and 2005 were examined. Of the 494 patients who relapsed, 125 had raised LDH at the time of relapse. 112 of these had a concurrent rise in either AFP, HCG or both, 11 had their disease detected on CT before the rise in LDH, one had a clinically palpable para-aortic mass and the final patient complained of back pain and his retroperitoneal disease was thus discovered on imaging. Routine measurement of LDH in patients on surveillance for stage I germ cell tumours does not add to the early detection of relapse.

References

Nov 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G ReadP A Cook

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Citations

Nov 3, 2016·Nature Reviews. Urology·Matthew J MurrayNicholas Coleman
Apr 10, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gordon J RustinUNKNOWN National Cancer Research Institute Testis Cancer Clinical Studies Group
Aug 20, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christian KollmannsbergerCraig R Nichols
Jun 10, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Timothy D GilliganUNKNOWN American Society of Clinical Oncology
Apr 21, 2012·Cancer·Danny VespriniPadraig Warde
Nov 12, 2010·Nature Reviews. Urology·LaMont J BarlowJames M McKiernan
Aug 17, 2020·American Journal of Clinical Oncology·Clint CaryLawrence H Einhorn
Jan 26, 2021·Critical Reviews in Oncology/hematology·Paolo PedrazzoliSimona Secondino
Apr 4, 2021·International Journal of Molecular Sciences·João LoboRui Henrique
Sep 9, 2010·Urologic Oncology·Yaron EhrlichLawrence H Einhorn
Dec 3, 2021·World Journal of Urology·Maximilian Peter BrandtUNKNOWN GESRU Academics Testis, Penile Cancer Group

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