PMID: 2477588Jan 1, 1989Paper

[Lactate dehydrogenase isoenzymes in radiation therapy of cancer patients].

Laboratornoe delo
I A KlimovN B Elistratova

Abstract

Changes in the lactate dehydrogenase (LDH) isozymic spectrum have been examined in the patients with Stages I-III malignant tumors of the uterus before radiation therapy, during radiation reactions, and after these reactions have been remedied with polydesum and aminocaproic acid. A comparative analysis has shown that the blood serum LDH isozymic spectrum is changed in oncologic patients mainly at the expense of increased content of LDH4 and LDH5. Radiation reactions are associated with a considerable reduction of LDH1 activity and an essential rise of LDH3 and LDH4 activities, and an insignificant elevation of LDH2. The detected shifts in LDH isozymic spectrum during radiation reactions appear to be due to radiation toxemia. Detoxifying therapy with polydesum and epsilon-aminocaproic acid during 3-5 days helped normalize the LDH isozymic ratio.

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Zhonghua zheng xing shao shang wai ke za zhi = Zhonghua zheng xing shao shang waikf [i.e. waike] zazhi = Chinese journal of plastic surgery and burns
J H Li
Indian Journal of Pathology & Microbiology
P KhuranaS P Tyagi
© 2022 Meta ULC. All rights reserved