Jan 1, 1989

Lactate dehydrogenase isoenzymes in radiation therapy of cancer patients

Laboratornoe delo
I A KlimovN B Elistratova


Changes in the lactate dehydrogenase (LDH) isozymic spectrum have been examined in the patients with Stages I-III malignant tumors of the uterus before radiation therapy, during radiation reactions, and after these reactions have been remedied with polydesum and aminocaproic acid. A comparative analysis has shown that the blood serum LDH isozymic spectrum is changed in oncologic patients mainly at the expense of increased content of LDH4 and LDH5. Radiation reactions are associated with a considerable reduction of LDH1 activity and an essential rise of LDH3 and LDH4 activities, and an insignificant elevation of LDH2. The detected shifts in LDH isozymic spectrum during radiation reactions appear to be due to radiation toxemia. Detoxifying therapy with polydesum and epsilon-aminocaproic acid during 3-5 days helped normalize the LDH isozymic ratio.

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Mentioned in this Paper

Lactate Dehydrogenase Isoenzyme 3 Measurement
Aminocaproic Acids
Entire Uterus
Septic Toxemia
Neoplasm of Uncertain or Unknown Behavior of Uterus
Lactic acid dehydrogenase isoenzyme 3
Uterine Cancer

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