Lactate increase and oxygen desaturation in mitochondrial disorders--evaluation of two diagnostic screening protocols.

Journal of Neurology
Frank HanischStephan Zierz

Abstract

Mitochondrial disorders are characterized by an accumulation of lactate and an insufficient oxygen extraction from blood during exercise. Therefore, both parameters (lactate and oxygen saturation) can be used as screening tests in mitochondrial disorders. However, conflicting results regarding sensitivities and specifities of both tests have been reported. We examined 27 patients with genetically defined mitochondrial disorders (single deletions n = 15, multiple deletions n = 5, A3243G mutation n = 7), patients with other neuromuscular disorders, and healthy controls. In the first test subjects performed intermittent isometric handgrip exercise (0.5 Hz) at 80% (3 minutes) and 30% (3 and 15 minutes) of maximal contraction force (MCF). Oxygen saturation and partial pressure in cubital venous blood from the exercising arm were measured. In the second test subjects underwent cycle ergometry at 30 W for 15 minutes. Venous lactate at rest, during and 15 minutes postexercise was determined. Both tests showed specificities of 92-96%. Sensitivities for changes of venous oxygen partial pressure and oxygen saturation ranged from 21-26% at 80% MCF for 3 minutes to 47-58% at 30% MCF for 15 minutes. Sensitivities for venous resting, peak, an...Continue Reading

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Citations

Apr 5, 2013·Zeitschrift für Rheumatologie·M Vorgerd, M Deschauer
Mar 5, 2011·Musculoskeletal Surgery·L VolpiG Siciliano
Oct 15, 2014·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Pushpa Raj JoshiFrank Hanisch
Jan 14, 2012·Physical Medicine and Rehabilitation Clinics of North America·Mark Tarnopolsky
Mar 1, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Vincent O BoerDennis W J Klomp
Jun 12, 2012·Clinical Physiology and Functional Imaging·Amèle MouadilFrançoise Chapon
Aug 22, 2014·Journal of Neurology, Neurosurgery, and Psychiatry·Frank HanischStephan Zierz
Jan 16, 2014·Molecular Genetics and Metabolism·S M SirrsC D M van Karnebeek
Sep 3, 2010·Journal of Intensive Care Medicine·Nicholas C Watson, Stephen O Heard
Jul 5, 2008·Expert Review of Molecular Diagnostics·Gabriele SicilianoLuigi Murri

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