Lactate indices as predictors of in-hospital mortality or 90-day survival after admission to an intensive care unit in unselected critically ill patients

PloS One
Yusuke HayashiMasakazu Nitta

Abstract

We performed an exclusive study to investigate the associations between a total of 23 lactate-related indices during the first 24h in an intensive care unit (ICU) and in-hospital mortality. Nine static and 14 dynamic lactate indices, including changes in lactate concentrations (Δ Lac) and slope (linear regression coefficient), were calculated from individual critically ill patient data extracted from the Multiparameter Intelligent Monitoring for Intensive Care (MIMIC) III database. Data from a total of 781 ICU patients were extracted, consisted of 523 survivors and 258 non-survivors. The in-hospital mortality rate for this cohort was 33.0%. A multivariate logistic regression model identified maximal lactate concentration at 24h after ICU admission (max lactate at T24) as a significant predictor of in-hospital mortality (odds ratio = 1.431, 95% confidence interval [CI] = 1.278-1.604, p<0.001) after adjusting for predefined confounders (age, gender, sepsis, Elixhauser comorbidity score, mechanical ventilation, renal replacement therapy, vasopressors, ICU severity scores). Area under curve (AUC) for max lactate at T24 was larger (AUC = 0.776, 95% CI = 0.740-0.812) than other indices (p<0.001), comparable to an APACHE III score of ...Continue Reading

References

Jun 1, 1983·Critical Care Medicine·J L VincentR J Kahn
Feb 7, 1998·Medical Care·A ElixhauserR M Coffey
Aug 3, 2004·Critical Care Medicine·H Bryant NguyenMichael C Tomlanovich
Apr 14, 2007·Intensive Care Medicine·Stephen TrzeciakJoseph E Parrillo
Dec 19, 2008·Critical Care : the Official Journal of the Critical Care Forum·Tim C JansenJan Bakker
Oct 22, 2011·Critical Care : the Official Journal of the Critical Care Forum·Alistair NicholRinaldo Bellomo
Oct 2, 2013·Mayo Clinic Proceedings·Lars W AndersenMichael W Donnino
Apr 16, 2014·Journal of Intensive Care Medicine·Ari MoskowitzJohn Danziger
Dec 11, 2014·The New England Journal of Medicine·Jeffrey A Kraut, Nicolaos E Madias
May 25, 2016·Scientific Data·Alistair E W JohnsonRoger G Mark
Aug 16, 2016·Critical Care : the Official Journal of the Critical Care Forum·Jean-Louis VincentFabio S Taccone
Jul 15, 2017·Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine·Ralphe Bou CheblGilbert Abou Dagher
May 14, 2018·Intensive Care Medicine·Glenn HernandezJan Bakker
May 17, 2018·Critical Care Medicine·Mitchell M LevyAndrew Rhodes
Nov 26, 2018·The American Journal of Emergency Medicine·Francisco Martín-RodríguezCarlos Del Pozo Vegas
Nov 28, 2018·Intensive Care Medicine·Maryna MasyukChristian Jung
May 2, 2019·Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine·Zhiqiang LiuHeshui Wu

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Citations

Mar 20, 2021·Scientific Reports·Nozomi TakahashiJames A Russell
May 29, 2021·BMC Endocrine Disorders·Jingwei LiuYumei Li
Jun 1, 2021·Frontiers in Medicine·Dominik JarczakAxel Nierhaus
Jul 2, 2021·International Journal of General Medicine·Yu ChenWenliang Tan

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