PMID: 9659671Jul 11, 1998Paper

Lactate production and clearance in exercise. Effects of training. A mini-review

Scandinavian Journal of Medicine & Science in Sports
B StallknechtH Galbo

Abstract

Lactate accumulates if pyruvate formation exceeds pyruvate oxidation. Accelerated glycogenolysis is essential for lactate production. Glycogen and epinephrine enhance glycogen phosphorylase activity and this is higher in type II b than in type I fibers. Pyruvate oxidation is enhanced by exercise-induced increase in pyruvate dehydrogenase activity and is relatively impaired by low oxygen availability and low mitochondrial oxidative capacity. During exercise lactate is eliminated in liver, heart, and resting and working muscle. In muscle, elimination depends on plasma concentration, fiber type, and fiber conditions. Due to influence on hormonal response, mitochondrial oxidative capacity and fiber recruitment, training diminishes glycogenolysis and lactate production. Training also increases lactate clearance. This reflects increased hepatic capacity for gluconeogenesis as well as increased lactate transport capacity and oxidative capacity and reduced glycogenolysis in muscle. The fact that endurance performance can be predicted from the plasma lactate versus exercise intensity relationship illustrates that the plasma lactate level is a finely balanced result of the interplay between many factors of importance for endurance exercise.

References

Mar 1, 1976·Acta Physiologica Scandinavica·B SaltinD Gollnick
Jul 14, 1978·Biochemical and Biophysical Research Communications·K M BaldwinR E Herrick
Aug 1, 1977·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·K M BaldwinD A Cooke
Jul 1, 1992·British Medical Bulletin·N C Spurway
May 1, 1992·Journal of Applied Physiology·H S MacRaeT D Noakes
May 1, 1992·Journal of Applied Physiology·J VissingR G Haller
Dec 1, 1991·Acta Physiologica Scandinavica·D Constantin-TeodosiuE Hultman
Mar 1, 1991·The Journal of Physiology·J BangsboB Saltin
Apr 1, 1986·Journal of Applied Physiology·W C StanleyG A Brooks
Aug 1, 1987·The American Journal of Physiology·S H ConstableJ O Holloszy
Dec 1, 1971·The Journal of Clinical Investigation·J WahrenL Jorfeldt
Nov 1, 1982·Acta Physiologica Scandinavica·E A RichterH Galbo
Dec 1, 1993·Acta Physiologica Scandinavica·L KaijserB Berglund
Feb 1, 1994·Journal of Applied Physiology·C Duan, W W Winder
Feb 1, 1993·Journal of Applied Physiology·K D SumidaC M Donovan
Oct 1, 1996·Annals of Neurology·J VissingR G Haller
Apr 1, 1997·Physiological Reviews·C Juel

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Citations

Feb 1, 2006·Sports Medicine·Blair CrewtherJustin Keogh
Mar 31, 2012·Research in Sports Medicine·Julien S BakerRobert A Robergs
Jan 6, 2016·European Journal of Applied Physiology·Simon AnnaheimUrs Boutellier
Mar 24, 2017·Sports Medicine·Luc Tappy, Robin Rosset
May 8, 2020·Physiological Reports·Steffen WillwacherGrischa Bratke
Feb 11, 2005·European Journal of Applied Physiology·J M GreenA Redden
Sep 22, 2009·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Keith TolfreyAndrew M Jones
Oct 31, 2018·Frontiers in Endocrinology·Hirokazu TakahashiKeizo Anzai
Aug 24, 2019·Frontiers in Integrative Neuroscience·Stephanie T YulindaMelaniani Soenarnatalina
Oct 20, 2010·European Journal of Applied Physiology·Fabio R SerpielloRobert J Aughey
Mar 5, 2004·Journal of Sports Sciences·Omar Ali AlmarwaeyKeith Tolfrey
Sep 18, 2014·International Journal of Sports Physiology and Performance·Peter M Christensen, Jens Bangsbo
Dec 15, 2012·Journal of Applied Physiology·Chi-An W EmhoffGeorge A Brooks
Nov 10, 2020·Physiological Measurement·Denis MonginD S Courvoisier
Mar 8, 2019·Journal of Strength and Conditioning Research·Danilo Gomes MoreiraManuel Sillero-Quintana
Aug 5, 2009·Paediatric Respiratory Reviews·Greg D Wells, Stephen R Norris

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