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Lactate reduces epileptiform activity through HCA1 and GIRK channel activation in rat subicular neurons in an in vitro model

Epilepsia

Nov 23, 2019

Pooja Jorwal, Sujit Kumar Sikdar

Abstract

Much evidence suggests that the subiculum plays a significant role in the regulation of epileptic activity. Lactate acts as a neuroprotective agent against many conditions that cause brain damage. During epileptic seizures, lactate formation reaches up to ~6 mmol/L in the brain. We inve...read more

Mentioned in this Paper

Study
Brain Injuries
Patch-Clamp Techniques
Immunohistochemistry
Anticonvulsants
G Protein-Coupled Inwardly-Rectifying Potassium Channels
Regulation of Biological Process
Epilepsy
Neurons
Brain
7
1
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Lactate reduces epileptiform activity through HCA1 and GIRK channel activation in rat subicular neurons in an in vitro model

Epilepsia

Nov 23, 2019

Pooja Jorwal, Sujit Kumar Sikdar

PMID: 31755997

DOI: 10.1111/epi.16389

Abstract

Much evidence suggests that the subiculum plays a significant role in the regulation of epileptic activity. Lactate acts as a neuroprotective agent against many conditions that cause brain damage. During epileptic seizures, lactate formation reaches up to ~6 mmol/L in the brain. We inve...read more

Mentioned in this Paper

Study
Brain Injuries
Patch-Clamp Techniques
Immunohistochemistry
Anticonvulsants
G Protein-Coupled Inwardly-Rectifying Potassium Channels
Regulation of Biological Process
Epilepsy
Neurons
Brain
7
1

Similar Papers Found In These Feeds

Limbic System

The limbic system is comprised of several different parts of the brain involved in emotion, motivation, learning, and memory. Discover the latest research on the limbic system here.

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

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  • finger pointing at paper

    References currently unavailable

    We're still populating references for this paper, please check back later.
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