Lactate secreted by cervical cancer cells modulates macrophage phenotype

Journal of Leukocyte Biology
Simone Cardozo StoneAna Paula Lepique

Abstract

Cervical cancer continues to be a public health problem in developing countries. Previous studies have shown that cervical cancer cells display markers of aerobic glycolysis, indicating that these tumors are likely to secrete lactate. Mostly, lactate is recognized as a molecule capable of suppressing immune responses, through inhibition of T cells, Mϕs, and dendritic cells. We and others have previously shown that Mϕs are frequent cells infiltrating cervical cancers with the ability to inhibit antitumor immune responses and promote tumor growth through angiogenesis. Here, we have tested the hypothesis that lactate, secreted by cervical cancer cells, can modulate Mϕ phenotype. First, we showed higher lactate plasma concentrations in patients with increasing cervical lesion grades, with maximum concentration in the plasma of cancer patients, which supported our hypothesis. We then inhibited lactate production in tumor cell spheroids established from cervical cancer derived cell lines, using the lactate dehydrogenase inhibitor, oxamate, prior to co-culture with monocytes. Lactate mediated part of the crosstalk between tumor cells and Mϕs, promoting secretion of IL-1β, IL-10, IL-6, and up-regulation of hypoxia induced factor-1α exp...Continue Reading

References

Aug 19, 1999·The Journal of Pathology·J M WalboomersN Muñoz
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Oct 5, 2007·Critical Reviews in Oncology/hematology·Paola AllavenaAlberto Mantovani
Jan 8, 2008·Cell Metabolism·Ralph J DeBerardinisCraig B Thompson
Apr 9, 2008·Neoplasia : an International Journal for Oncology Research·Jessica C PahlerDouglas Hanahan
Aug 30, 2008·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Céline PinheiroFátima Baltazar
Dec 17, 2008·Mucosal Immunology·A KobayashiK Smith-McCune
Feb 10, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Devadoss J SamuvelYan Huang
Jun 25, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ana Paula LepiqueLuisa Lina Villa
Sep 8, 2010·Carcinogenesis·Enrique BoccardoLuisa L Villa
Nov 3, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Cornelia L TrimbleAchim A Jungbluth
May 6, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dagmar Von BubnoffThomas Bieber
Jun 29, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Moniek HeusinkveldSjoerd H van der Burg
Mar 15, 2012·Seminars in Cancer Biology·Eva GottfriedAndreas Mackensen
Jan 25, 2014·Cell Death & Disease·Y SuhM Tavassoli
Jun 21, 2014·Journal of the National Cancer Institute·Seiji MabuchiTadashi Kimura
Jul 17, 2014·Virchows Archiv : an International Journal of Pathology·Rosemarie KruparAnja K Bosserhoff
Nov 18, 2014·Immunity, Inflammation and Disease·Simone Cardozo StoneAna Paula Lepique
Dec 17, 2014·Frontiers in Immunology·Nan WangKe Zen
Jan 15, 2015·Biochemical and Biophysical Research Communications·Katrin PeterMarina Kreutz
Sep 2, 2015·The Journal of Clinical Investigation·Stefano UgelVincenzo Bronte
Feb 26, 2016·Frontiers in Immunology·Susana Romero-GarciaFrancisco Javier Sánchez-García
Jan 5, 2017·Proceedings of the National Academy of Sciences of the United States of America·Peiwen ChenYihong Wan
Mar 25, 2017·Frontiers in Immunology·Kathrin RennerMarina Kreutz
Oct 7, 2017·Cell·Brandon FaubertRalph J DeBerardinis
Dec 8, 2017·Biomolecules & Therapeutics·Soo-Youl Kim
Jun 20, 2018·Journal for Immunotherapy of Cancer·Robert D Leone, Leisha A Emens
Nov 1, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Brian W LabadieJason J Luke

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Citations

May 22, 2019·The Journal of Clinical Investigation·Deepak Kumar KaushikV Wee Yong
Jul 10, 2019·International Journal of Molecular Sciences·Qun WangHelene Heidegger
Jul 1, 2020·Journal of Drug Targeting·Xiaoyu ZhangYanhong Wang
Sep 5, 2020·OncoTargets and Therapy·Luopei Guo, Keqin Hua
Feb 23, 2020·BioMed Research International·Yi LiuXia Zhao
Aug 9, 2020·Frontiers in Cell and Developmental Biology·Xiangyu SunYingying Xu
Dec 10, 2020·Cells·Dimas Carolina BelisarioChiara Riganti
Jan 28, 2020·Trends in Cell Biology·Shohini Ghosh-ChoudharyToren Finkel
Aug 18, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Dun NiuZhizhong Xie
Aug 17, 2021·Frontiers in Immunology·Indumathi ManoharanSanthakumar Manicassamy
Nov 14, 2020·Cellular and Molecular Bioengineering·Rapeepat SangsuwanJamal S Lewis
Oct 17, 2021·Journal of Hematology & Oncology·Yiyin ZhangHui Lin

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