Lactic acid bacteria--20 years exploring their potential as live vectors for mucosal vaccination

Applied Microbiology and Biotechnology
Agnieszka WyszyńskaElżbieta Katarzyna Jagusztyn-Krynicka

Abstract

Lactic acid bacteria (LAB) are a diverse group of Gram-positive, nonsporulating, low G + C content bacteria. Many of them have been given generally regarded as safe status. Over the past two decades, intensive genetic and molecular research carried out on LAB, mainly Lactococcus lactis and some species of the Lactobacillus genus, has revealed new, potential biomedical LAB applications, including the use of LAB as adjuvants, immunostimulators, or therapeutic drug delivery systems, or as factories to produce therapeutic molecules. LAB enable immunization via the mucosal route, which increases effectiveness against pathogens that use the mucosa as the major route of entry into the human body. In this review, we concentrate on the encouraging application of Lactococcus and Lactobacillus genera for the development of live mucosal vaccines. First, we present the progress that has recently been made in the field of developing tools for LAB genetic manipulations, which has resulted in the successful expression of many bacterial, parasitic, and viral antigens in LAB strains. Next, we discuss the factors influencing the efficacy of the constructed vaccine prototypes that have been tested in various animal models. Apart from the research ...Continue Reading

References

Apr 1, 1995·Applied and Environmental Microbiology·L SteidlerE Remaut
Jul 1, 1997·Applied and Environmental Microbiology·G BuistJ Kok
Jun 22, 2001·Journal of Bacteriology·Y DieyeJ C Piard
Feb 2, 2002·Applied and Environmental Microbiology·L G Bermúdez-HumaránYves Le Loir
Dec 9, 2003·FEMS Microbiology Letters·Naima G Cortes-PerezRoberto Montes-de-Oca-Luna
Apr 23, 2004·Infection and Immunity·Corinne GrangetteAnnick Mercenier
May 5, 2004·Best Practice & Research. Clinical Gastroenterology·Erika IsolauriArthur C Ouwehand
Aug 20, 2004·Journal of Bacteriology·Peter A BronMichiel Kleerebezem
Sep 4, 2004·Applied and Environmental Microbiology·D Llull, I Poquet
Jan 7, 2005·Applied Microbiology and Biotechnology·A R RahaH L Foo
Aug 10, 2005·Applied Microbiology and Biotechnology·Igor Mierau, Michiel Kleerebezem
Oct 22, 2005·Journal of Applied Microbiology·C A PerezD Mendoza
Jan 5, 2006·Applied and Environmental Microbiology·Tjibbe BosmaKees Leenhouts
Jan 18, 2006·Methods : a Companion to Methods in Enzymology·Maarten L van RoosmalenKees Leenhouts
Mar 15, 2006·Journal of Medical Microbiology·Daniela M FerreiraLuciana C C Leite
Sep 12, 2006·Applied and Environmental Microbiology·Valéria Dellaretti GuimarãesJean-Marc Chatel
Nov 4, 2006·Vaccine·Sandrine A L AudouyPeter W M Hermans
Dec 28, 2006·The Journal of Infectious Diseases·Sean B HanniffyJerry M Wells
Feb 7, 2007·Expert Review of Vaccines·Damini DaudelSimone Spreng
Oct 16, 2007·International Journal of Medical Microbiology : IJMM·Christoph SchoenJochen Stritzker
Oct 25, 2007·Journal of Molecular Microbiology and Biotechnology·E MorelloI Poquet
Mar 18, 2008·Nature Reviews. Microbiology·Jerry M Wells, Annick Mercenier

❮ Previous
Next ❯

Citations

Mar 1, 2016·Frontiers in Microbiology·Patrycja A KobiereckaAgnieszka K Wyszyńska
Sep 13, 2015·Applied Microbiology and Biotechnology·Seiichi TaguchiHiromi Matsusaki
Oct 5, 2016·Food Microbiology·Ewelina StefanovicOlivia McAuliffe
Dec 3, 2016·Human Vaccines & Immunotherapeutics·Isabelle LegasteloisBettina Werle
Mar 24, 2018·Medical Sciences : Open Access Journal·Valentina Yurina
Mar 13, 2018·Annual Review of Biomedical Engineering·Josef R BoberNikhil U Nair
Nov 7, 2016·Applied and Environmental Microbiology·Katarzyna KuczkowskaVincent G H Eijsink
Feb 9, 2018·Scientific Reports·Dasun WagachchiThomas Proft
Aug 24, 2017·FEMS Microbiology Reviews·Jan KokOscar P Kuipers
Jun 9, 2019·Applied Microbiology and Biotechnology·Keita TakahashiNaoki Inoue
Oct 20, 2018·Frontiers in Microbiology·Courtney Klotz, Rodolphe Barrangou
Apr 6, 2019·Journal of Immunology Research·E CriscuoloN Clementi
Jun 15, 2017·Indian Journal of Microbiology·P PriyodipS Balaji
Mar 28, 2019·Applied Microbiology and Biotechnology·Boyu JiangGuoqiang Zhu
Aug 21, 2018·Frontiers in Microbiology·Peter A Bron, Michiel Kleerebezem
Jul 7, 2017·Microbial Cell Factories·Yongping XinJian Kong
Dec 29, 2020·Critical Reviews in Food Science and Nutrition·Silpa S, Rupachandra S

❮ Previous
Next ❯

Related Concepts

Related Feeds

Avian Influenza: Innate Immune Adjuvant (ASM)

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.

Avian Influenza: Innate Immune Adjuvant

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.