Lactic acid bacteria efficiently protect human and animal intestinal epithelial and immune cells from enteric virus infection.

International Journal of Food Microbiology
Petros A MaragkoudakisAvrelija Cencic

Abstract

This study aimed to examine the potential antiviral activity of lactic acid bacteria (LAB) using animal and human intestinal and macrophage cell line models of non tumor origin. To this end, LAB strains selected on the basis of previous in vitro trials were co-incubated with cell line monolayers, which were subsequently challenged with rotavirus (RV) and transmissible gastroenteritis virus (TGEV). In order to elucidate the possible mechanism responsible for the antiviral activity, the induction of reactive oxygen species (ROS) release as well as the attachment ability of LAB on the cell lines was investigated. Various strains were found to exhibit moderate to complete monolayer protection against viral RV or TGEV disruption. Highest protection effects were recorded with the known probiotics Lactobacillus rhamnosus GG and Lactobacillus casei Shirota against both RV and TGEV, while notable antiviral activity was also attributed to Enterococcus faecium PCK38, Lactobacillus fermentum ACA-DC179, Lactobacillus pentosus PCA227 and Lactobacillus plantarum PCA236 and PCS22, depending on the cell line and virus combination used. A variable increase (of up to 50%) on the release of NO(-) and H(2)O(2) (ROS) was obtained when LAB strains we...Continue Reading

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Citations

Dec 14, 2011·Applied Microbiology and Biotechnology·Shen-Shih Chiang, Tzu-Ming Pan
Dec 12, 2012·Journal of Medicinal Food·Su-Jin OhHan-Joon Hwang
Mar 4, 2014·PloS One·Antonio Rubio-del-CampoJesús Rodríguez-Díaz
Nov 10, 2012·World Journal of Gastroenterology : WJG·Hanna VentolaReetta Holma
Aug 3, 2014·Food Microbiology·Dong Joo SeoChangsun Choi
May 17, 2012·Applied Microbiology and Biotechnology·Irene AloisioDiana Di Gioia
Jun 2, 2014·Probiotics and Antimicrobial Proteins·I Al KassaaD Drider
Mar 23, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Walter ChingwaruAvrelija Cencic
Sep 11, 2013·Brain, Behavior, and Immunity·Martin Manuel PalomarGabriela Perdigón
Jun 21, 2015·FEMS Microbiology Ecology·Soyoung YeoWilhelm Holzapfel
May 21, 2016·Frontiers in Microbiology·Empar ChenollJosé A Moreno Muñoz
Jul 5, 2016·Frontiers in Microbiology·Dan LiMieke Uyttendaele
Jul 12, 2016·International Journal of Food Microbiology·Diana Di GioiaJordi Rovira
Jul 15, 2004·Advances in Applied Microbiology·Paul Naaber, Marika Mikelsaar
Jul 12, 2018·Critical Reviews in Food Science and Nutrition·Murphy Lam Yim WanHani El-Nezami
Jul 8, 2011·Journal of Pediatric Gastroenterology and Nutrition·Naflesia B O CorrêaLuciano A P Filho
Jun 22, 2017·Archives of Microbiology·Guadalupe Gonzalez-OchoaPatricia Tamez-Guerra
Sep 26, 2020·Frontiers in Microbiology·Santosh Kumar TiwariMichael L Chikindas

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Datasets Mentioned

BETA
PCA236

Methods Mentioned

BETA
PCA

Software Mentioned

StatGraphics Centurion XV

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