PMID: 12755477May 21, 2003Paper

Lactic acid bacteria: inhibition of angiotensin converting enzyme in vitro and in vivo

Antonie van Leeuwenhoek
Anders FuglsangNiels C B Nyborg

Abstract

A total of 26 strains of wild-type lactic acid bacteria, mainly belonging to Lactococcus lactis and Lactobacillus helveticus, were assayed in vitro for their ability to produce a milk fermentate with inhibitory activity towards angiotensin converting enzyme (ACE). It was clear that the test strains in this study, in general, produce inhibitory substances in varying amounts. Using a spectrophotometric assay based on amino group derivatization with ortho-phthaldialdehyde as a measure of relative peptide content, it was shown that there is a significant correlation between peptide formation and ACE inhibition, indicating that peptide measurement constitutes a convenient selection method. The effect of active fermentates on in vivo ACE activity was demonstrated in normotensive rats. The pressor effect of angiotensin I (0.3 microg/kg) upon intravenous injection was significantly lower when rats were pre-fed with milks fermented using two strains of Lactobacillus helveticus. An increased response to bradykinin (10 microg/kg, intravenously injected) was observed using one of these fermented milks. It is concluded that Lactobacillus helveticus produces substances which in vivo can give rise to an inhibition of ACE. The inhibition in vi...Continue Reading

Citations

Oct 23, 2010·Journal of Dairy Science·J C Rodríguez-FigueroaB Vallejo-Cordoba
Jun 24, 2020·FEMS Microbiology Letters·José María Coll-MarquésGaspar Pérez-Martínez
Jun 10, 2020·Nutrients·Harsh MathurPaul D Cotter
Feb 13, 2013·Journal of the Science of Food and Agriculture·Ana R MadureiraFrancisco X Malcata
Sep 16, 2011·Food Science and Technology International = Ciencia Y Tecnología De Los Alimentos Internacional·C Muro UristaA Téllez Jurado
Aug 6, 2016·Critical Reviews in Food Science and Nutrition·Stephanie P B Caligiuri, Grant N Pierce
Jun 12, 2019·Biology of Sex Differences·Alexander C RazaviLydia A Bazzano
Jun 24, 2010·Journal of the Science of Food and Agriculture·Ana B Garcia-RedondoMercedes Salaices
Apr 24, 2009·Journal of Hypertension·Lotte UsingerLars T Jensen
Feb 27, 2015·Asian-Australasian Journal of Animal Sciences·N NahariahA Hintono
Feb 9, 2016·Critical Reviews in Food Science and Nutrition·Saira SultanMunawar Abbas
Sep 8, 2015·Journal of Food Science and Technology·Z F BhatHina Fayaz Bhat
Nov 1, 2016·Current Opinion in Nephrology and Hypertension·Meirav Pevsner-FischerEran Elinav
Apr 4, 2017·Current Hypertension Reports·David J Durgan
Dec 31, 2016·Food Science and Biotechnology·Alaa Abd El-FattahHany Elkashef
Jun 14, 2018·Current Hypertension Reviews·Vasiliki KatsiDimitrios Tousoulis
Sep 29, 2018·Food Science and Biotechnology·Alaa Abd El-FattahHany Elkashef
Jan 24, 2008·Journal of Food Science·L Ramchandran, N P Shah
Apr 27, 2021·Heliyon·Anita ChaudharyGirish Sahni
Jun 1, 2021·Frontiers in Bioengineering and Biotechnology·Yaqi WangWeitao Geng
Feb 13, 2007·Current Opinion in Biotechnology·Rainer Hartmann, Hans Meisel
Mar 31, 2011·Journal of Agricultural and Food Chemistry·Chin Feng LiuTzu Ming Pan
Dec 28, 2010·Advances in Colloid and Interface Science·Blanca Hernández-LedesmaIsidra Recio

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.