Lactic acid Bacteria isolated from European badgers (Meles meles) reduce the viability and survival of Bacillus Calmette-Guerin (BCG) vaccine and influence the immune response to BCG in a human macrophage model

BMC Microbiology
Anna StedmanJorge Gutierrez-Merino

Abstract

Bovine tuberculosis (bTB) caused by Mycobacterium bovis is the most serious endemic disease affecting livestock in the UK. The European badger (Meles meles) is the most important wildlife reservoir of bTB transmission to cattle, making eradication particularly difficult. In this respect, oral vaccination with the attenuated M. bovis vaccine Bacillus Calmette-Guerin (BCG) has been suggested as a wide-scale intervention to reduce bTB infection in badgers. However, experimental studies show variable protection. Among the possibilities for this variation is that the resident gut bacteria may influence the success of oral vaccination in badgers; either through competitive exclusion and/or inhibition, or via effects on the host immune system. In order to explore this possibility, we have tested whether typical gut commensals such as Lactic Acid Bacteria (LAB) have the capacity to impact on the viability and survival rate of BCG and to modulate the immune response to BCG using an in vitro model. Twelve LAB isolated from badger faeces displayed inhibitory activity to BCG that was species-dependent. Weissella had a bacteriostatic effect, whereas isolates of enterococci, lactobacilli and pediococci had a more bactericidal activity. Furth...Continue Reading

References

Dec 1, 1988·Antimicrobial Agents and Chemotherapy·T L TalaricoW J Dobrogosz
Sep 5, 1997·Science·F R BlattnerY Shao
Apr 10, 1999·Letters in Applied Microbiology·T J MontvilleY Chen
Jan 29, 2000·Immunology and Cell Biology·J ChinA Mullbacher
Feb 12, 2002·International Journal of Systematic and Evolutionary Microbiology·Matthhew D CollinsNorbert Weiss
Oct 18, 2002·International Journal of Food Microbiology·R Paul RossC Hill
Jan 28, 2003·Critical Reviews in Microbiology·Frank J CarrNino Maida
Feb 5, 2003·Proceedings of the National Academy of Sciences of the United States of America·Michiel KleerebezemRoland J Siezen
Dec 18, 2003·Clinical and Experimental Immunology·F DriesslerA J Schottelius
Jul 19, 2008·Journal of Endodontics·Jung Eun BaikSeung Hyun Han
Apr 20, 2010·International Journal of Food Microbiology·Haider KhanPak-Lam Yu
Jun 16, 2010·International Journal of Antimicrobial Agents·James CarrollJim O'Mahony
Jul 29, 2010·Physiological Reviews·Inna SekirovB Brett Finlay
Jul 29, 2010·Nature Reviews. Gastroenterology & Hepatology·Mélanie G GareauW Allan Walker
Dec 3, 2010·Proceedings. Biological Sciences·Mark A ChambersR Glyn Hewinson
Apr 1, 2011·Veterinary Microbiology·Gavin J WilsonRichard J Delahay
Apr 7, 2011·Bioengineered Bugs·John Donaghy
Sep 8, 2011·Current Opinion in Gastroenterology·Fang Yan, D B Polk
Feb 3, 2012·Cold Spring Harbor Perspectives in Biology·Kim Newton, Vishva M Dixit
Feb 22, 2012·Comparative Immunology, Microbiology and Infectious Diseases·Philip A RobinsonDarrell A Abernethy
Mar 23, 2012·Immunological Reviews·Manolis Pasparakis
Aug 25, 2012·Frontiers in Cellular and Infection Microbiology·Enrica Pessione
Oct 6, 2012·Annals of Nutrition & Metabolism·Miriam Bermudez-BritoAngel Gil
Jul 24, 2013·Microbial Cell Factories·Rebeca MartínLuis G Bermúdez-Humarán
Jan 16, 2014·Research in Veterinary Science·Joanne L HardstaffPiran C L White
Oct 22, 2014·Probiotics and Antimicrobial Proteins·Hanne JensenStine Grimmer
Apr 9, 2015·Frontiers in Microbiology·Vincenzina FuscoCharles M A P Franz
Apr 11, 2015·BioMed Research International·Juan L ArquésMargarita Medina

❮ Previous
Next ❯

Citations

Feb 7, 2020·Annals of the New York Academy of Sciences·Anna StedmanJorge Gutierrez-Merino
Aug 6, 2020·Frontiers in Microbiology·Pooja AgarwalFernando O Martinez
Nov 11, 2019·ACS Biomaterials Science & Engineering·Farzad ForoutanDaniela Carta
Oct 21, 2021·Applied and Environmental Microbiology·Maria BravoJorge Gutierrez-Merino

❮ Previous
Next ❯

Methods Mentioned

BETA
PCA
Fluorescence
ELISA
PMA
FCS

Software Mentioned

GraphPad Prism

Related Concepts

Related Feeds

Antitubercular Agents

Antitubercular agents are pharmacologic agents for treatment of tuberculosis. Discover the latest research on antitubercular agents here.

Avian Influenza: Innate Immune Adjuvant (ASM)

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Avian Influenza: Innate Immune Adjuvant

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Antitubercular Agents (ASM)

Antitubercular agents are pharmacologic agents for treatment of tuberculosis. Discover the latest research on antitubercular agents here.