Lactic acid bacteria-specific induction of CD4+ Foxp3+ T cells ameliorates shrimp tropomyosin-induced allergic response in mice via suppression of mTOR signaling

Scientific Reports
Linglin FuYanbo Wang

Abstract

The beneficial effects of probiotics have been described in allergic sensitization and diseases; however, many questions remain unanswered, such as characteristics of the most effective strains in modulation of allergic responses and how orally administered probiotics affect the systemic immune system. In the present work, oral administration of five lactic acid bacteria strains showed variable effects on protection against the allergic reaction in a mouse model of food allergy to shrimp tropomyosin (ST). The most effective anti-allergic strain, Bacillus coagulans 09.712 (Bc), greatly improved epithelial barrier function and increased lymphocytes proliferation. Moreover, Bc suppresses ST sensitization by altering Th1/Th2/Treg balance as a result of strong induction of CD4+Foxp3+Tregs in combination with IL-10 producing. Bc-specific induction of CD4+Foxp3+ Tregs also suppresses Th17 pro-inflammatory response in this mouse model. Finally, the intake of Bc suppresses mTOR activation and thus the phosphorylation of downstream factors. Inhibition of mTOR signaling by Bc further results in FOXP3 up-regulation and GATA-3 down-regulation, which, in turn, facilitate to control Th2-predominant and Th17 pro-inflammatory responses caused b...Continue Reading

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Citations

Aug 3, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Luc ColasUNKNOWN DIVAT Consortium
Feb 27, 2020·International Journal of Molecular Sciences·Massimo De MartinisLia Ginaldi
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Apr 3, 2020·Archivum Immunologiae Et Therapiae Experimentalis·Massimo De MartinisLia Ginaldi

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Methods Mentioned

BETA
ELISA
FACS
PCR
FCS
electrophoresis
fluorescence imaging

Software Mentioned

Summit
SPSS

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