PMID: 8597616Feb 1, 1996Paper

Lactic acidosis and hypoglycemia in a patient with high-grade non-Hodgkin's lymphoma and elevated circulating TNF-alpha

Annals of Hematology
J DurigD K Hossfeld

Abstract

A 71-year-old patient with high-grade non-Hodgkin's lymphoma stage IVB, severe lactic acidosis and tumor-associated hypoglycemia is described. Endocrine causes of hypoglycemic episodes were excluded because of low serum concentrations of insulin and "insulin-like growth factor 1", and normal concentrations of growth hormone and thyroid hormone. Clinical conditions associated with lactic acidosis such as diabetes mellitus, biguanide intoxication, septicemia, acute hypoxemia, or circulatory insufficiency were ruled out. Enhanced glucose metabolism within the tumor was visualized by positron emission tomography employing 2-fluro-2-deoxy-D-glucose (FDG) as a tracer. A markedly elevated tumor necrosis factor-alpha (TNF-alpha) level was found which decreased after cytoreductive therapy paralleling the normalization of serum lactate. In contrast to the majority of cases of lymphoma-associated lactic acidoses reviewed to date, in our case lactate elimination was not reduced.

References

Oct 1, 1990·The Journal of Surgical Research·J C JensenJ A Norton
Dec 1, 1988·The American Journal of Physiology·C M Liedtke
Apr 1, 1988·Southern Medical Journal·G C DoolittleD C Bodensteiner
Aug 27, 1987·The New England Journal of Medicine·I R GarrettG R Mundy
Jul 1, 1966·Annals of Internal Medicine·J B BlockW R Bell
Oct 1, 1983·American Journal of Clinical Pathology·D LuftM Eggstein

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Citations

Aug 12, 1999·FEMS Immunology and Medical Microbiology·M W Raza, C C Blackwell
Jan 14, 2010·Case Reports in Medicine·Farn Huei ChanLaurel J Lyckholm
Jan 14, 2005·International Journal of Hematology·Korenori OhtsuboMichio Sata
Jan 23, 2009·Leukemia & Lymphoma·Panagiotis AnagnostisFedon Harsoulis
Aug 19, 2015·Frontiers in Immunology·Sophia M MoscovisCaroline Blackwell
Jan 27, 2007·Blood·Karin FischerMarina Kreutz
May 1, 2009·Pediatric Blood & Cancer·Nathan LuscriJakub Tolar
Oct 12, 2012·The Journal of Clinical Endocrinology and Metabolism·Georges C ElhomsyGeorge T Griffing
Dec 19, 2013·The American Journal of Case Reports·Georges TaniosChirag B Patel
Oct 2, 2008·Journal of Pediatric Endocrinology & Metabolism : JPEM·Maynika V RastogiJ B Quintos

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