Lactic Acidosis in a Patient with Type 2 Diabetes Mellitus

Clinical Journal of the American Society of Nephrology : CJASN
Lawrence S Weisberg

Abstract

Lactic acidosis occurs when lactate production exceeds its metabolism. There are many possible causes of lactic acidosis, and in any given patient, several causes may coexist. This Attending Rounds presents a case in point. Metformin's role in the pathogenesis of lactic acidosis in patients with diabetes mellitus is complex, as the present case illustrates. The treatment of lactic acidosis is controversial, except for the imperative to remedy its underlying cause. The use of sodium bicarbonate to treat the often alarming metabolic derangements may be quite efficacious in that regard but is of questionable benefit to patients. Renal replacement therapies (RRTs) have particular appeal in this setting for a variety of reasons, but their effect on clinical outcomes is untested.

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Citations

Sep 4, 2020·BMJ Case Reports·Mohummad Shaan GoonooFionuala Creagh
Aug 3, 2019·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Isabelle H S KuanDaniel F B Wright
Mar 8, 2021·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Yoshio NagaiYasushi Tanaka
Mar 20, 2019·Open Life Sciences·Sarah Se-Jung OhJu-Hee Kang
May 26, 2021·Drug and Therapeutics Bulletin·Mohummad Shaan GoonooFionuala Creagh

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