PMID: 6023269May 19, 1967Paper

Lactic dehydrogenase and metabolism of human leukocytes in vitro

Science
A D BloomT Wajima

Abstract

During transformation and division of lymphocytes in culture, the lactic dehydrogenase isozymes migrate increasingly toward the cathode. With extension of the time in culture, the mitotic index declines, and the isozyme pattern reverts to dominance of those bands that move toward the anode, despite the cellular tendency to anaerobic metabolism. These findings suggest that synthesis of the more slowly migrating lactic dehydrogenase isozymes in this system is related to mitotic activity, and not to the aerobic or anaerobic conditions of cell culture.

References

Aug 1, 1965·Proceedings of the National Academy of Sciences of the United States of America·A D Rubin, H L Cooper
Oct 1, 1955·Proceedings of the Society for Experimental Biology and Medicine·F WROBLEWSKI, J S LADUE
Aug 1, 1963·Proceedings of the National Academy of Sciences of the United States of America·C R SHAW, E BARTO

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Citations

Mar 1, 1973·Biulleten' eksperimental'noĭ biologii i meditsiny·I G Dauronov
Dec 1, 1971·Clinica Chimica Acta; International Journal of Clinical Chemistry·S LindyK Vainio
Jan 1, 1972·Clinica Chimica Acta; International Journal of Clinical Chemistry·J UittoS Lindy
May 1, 1968·Comparative Biochemistry and Physiology·R P Francesconi, C A Villee
Feb 15, 1968·Life Sciences. Pt. 2: Biochemistry, General and Molecular Biology·M M ThalerC A Villee
Jan 1, 1971·Progress in Histochemistry and Cytochemistry·P J Melivick
Feb 1, 1969·Experimental Cell Research·P Hellung-Larsen, V Andersen
Oct 1, 1970·Experimental Cell Research·M R Quastel, J G Kaplan
Oct 1, 1972·Toxicology and Applied Pharmacology·G M Brenner, D G Wenzel
Jan 1, 1980·Journal of Immunological Methods·W De CockH Verhaegen
Jun 16, 1975·Biochemical and Biophysical Research Communications·A B Parkes, R D Howells
Jan 1, 1970·Acta Pathologica Et Microbiologica Scandinavica. Section A, Pathology·V AndersenP Hellung-Larsen
Aug 1, 1972·The Journal of Investigative Dermatology·J UittoL Danielsen

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