Lactobacilli Degrade Wheat Amylase Trypsin Inhibitors to Reduce Intestinal Dysfunction Induced by Immunogenic Wheat Proteins

Gastroenterology
Alberto CamineroElena F Verdu

Abstract

Wheat-related disorders, a spectrum of conditions induced by the ingestion of gluten-containing cereals, have been increasing in prevalence. Patients with celiac disease have gluten-specific immune responses, but the contribution of non-gluten proteins to symptoms in patients with celiac disease or other wheat-related disorders is controversial. C57BL/6 (control), Myd88-/-, Ticam1-/-, and Il15-/- mice were placed on diets that lacked wheat or gluten, with or without wheat amylase trypsin inhibitors (ATIs), for 1 week. Small intestine tissues were collected and intestinal intraepithelial lymphocytes (IELs) were measured; we also investigated gut permeability and intestinal transit. Control mice fed ATIs for 1 week were gavaged daily with Lactobacillus strains that had high or low ATI-degrading capacity. Nonobese diabetic/DQ8 mice were sensitized to gluten and fed an ATI diet, a gluten-containing diet or a diet with ATIs and gluten for 2 weeks. Mice were also treated with Lactobacillus strains that had high or low ATI-degrading capacity. Intestinal tissues were collected and IELs, gene expression, gut permeability and intestinal microbiota profiles were measured. In intestinal tissues from control mice, ATIs induced an innate imm...Continue Reading

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Citations

Jun 13, 2019·American Journal of Physiology. Gastrointestinal and Liver Physiology·Alberto Caminero, Elena F Verdu
Oct 11, 2019·Nutrients·Francesco ValituttiAlessio Fasano
Mar 19, 2020·International Journal of Molecular Sciences·Konstantinos EfthymakisMichele Sallese
Mar 4, 2020·Nature Reviews. Gastroenterology & Hepatology·Paul MoayyediPremysl Bercik
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Nov 19, 2019·Frontiers in Pharmacology·Si-Zhe WanXuan Zhu
Mar 29, 2020·Expert Review of Gastroenterology & Hepatology·Ruggiero FrancavillaMaria De Angelis
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Oct 5, 2019·Nutrients·Iva HoffmanováHelena Tlaskalová-Hogenová
Dec 25, 2019·Nature Structural & Molecular Biology·Elena F Verdu, Detlef Schuppan
Sep 2, 2020·Current Opinion in Gastroenterology·Alberto Caminero, M I Pinto-Sanchez
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Sep 17, 2021·Nature Reviews. Gastroenterology & Hepatology·M Ines Pinto-SanchezElena F Verdu
Oct 9, 2021·Current Opinion in Clinical Nutrition and Metabolic Care·Marta OlivaresYolanda Sanz
Jan 16, 2022·Mucosal Immunology·Heather J Galipeau, Elena F Verdu

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