Lactobacilli-lactoferrin interplay in Chlamydia trachomatis infection

Pathogens and Disease
Rosa SessaPiera Valenti

Abstract

In the cervicovaginal microenvironment, lactobacilli are known to protect against genital infections and, amongst the host defence compounds, lactoferrin has recently acquired importance for its anti-microbial and anti-inflammatory properties. An abnormal genital microenvironment facilitates the acquisition of pathogens like Chlamydia trachomatis, the leading cause of bacterial sexually transmitted infections worldwide. The aim of our study is to investigate the effects of Lactobacillus crispatus, Lactobacillus brevis and bovine lactoferrin on chlamydial infection, in order to shed light on the complex interplay between host defence mechanisms and C. trachomatis. We have also evaluated the effect of these defence factors to modulate the chlamydia-mediated inflammatory state. To this purpose, we have determined the infectivity and progeny production of C. trachomatis as well as interleukin-8 and interleukin-6 synthesis. The main result of our study is that the combination of L. brevis and bovine lactoferrin is the most effective in inhibiting the early phases (adhesion and invasion) of C. trachomatis infection of cervical epithelial cells and in decreasing the levels of both cytokines. In conclusion, the interaction between L. b...Continue Reading

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Citations

Apr 17, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Maria Stefania LepantoAntimo Cutone
Aug 5, 2017·Frontiers in Cellular and Infection Microbiology·Simone FilardoRosa Sessa
Apr 12, 2019·Scientific Reports·Simone FilardoIan N Clarke
Feb 26, 2019·The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien Des Maladies Infectieuses Et De La Microbiologie Médicale·Simone FilardoRosa Sessa
Jun 24, 2020·Frontiers in Immunology·Douglas B KellEtheresia Pretorius
Apr 30, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Romina MancinelliPiera Valenti
Mar 28, 2020·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Luigi RosaPiera Valenti
Mar 10, 2021·Critical Reviews in Food Science and Nutrition·Michał SienkiewiczJakub Fichna

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