Lactobacillus fermentum Improves Tacrolimus-Induced Hypertension by Restoring Vascular Redox State and Improving eNOS Coupling

Molecular Nutrition & Food Research
Marta ToralJuan Duarte

Abstract

The aim is to analyze whether the probiotic Lactobacillus fermentum CECT5716 (LC40) can prevent endothelial dysfunction and hypertension induced by tacrolimus in mice. Tacrolimus increases systolic blood pressure (SBP) and impairs endothelium-dependent relaxation to acetylcholine and these effects are partially prevented by LC40. Endothelial dysfunction induced by tacrolimus is related to both increased nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX2) and uncoupled endothelial nitric oxide synthase (eNOS)-driven superoxide production and Rho-kinase-mediated eNOS inhibition. LC40 treatment prevents all the aortic changes induced by tacrolimus. LC40 restores the imbalance between T-helper 17 (Th17)/regulatory T (Treg) cells induced by tacrolimus in mesenteric lymph nodes and the spleen. Tacrolimus-induced gut dysbiosis, that is, it decreases microbial diversity, increases the Firmicutes/Bacteroidetes (F/B) ratio and decreases acetate- and butyrate-producing bacteria, and these effects are prevented by LC40. Fecal microbiota transplantation (FMT) from LC40-treated mice to control mice prevents the increase in SBP and the impaired relaxation to acetylcholine induced by tacrolimus. LC40 treatment prevents hypertens...Continue Reading

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Citations

Jan 28, 2020·Microbial Biotechnology·Hui XuLu Cai
Dec 29, 2019·British Journal of Pharmacology·Iñaki Robles-VeraJuan Duarte
Nov 8, 2019·Molecular Nutrition & Food Research·Victoria L O'Morain, Dipak P Ramji
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Jan 4, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Iñaki Robles-VeraJuan Duarte
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