Lactobacillus gasseri PA-3, but not L. gasseri OLL2996, reduces the absorption of purine nucleosides in rats

Nucleosides, Nucleotides & Nucleic Acids
Hiroshi KanoH Ito

Abstract

Lactobacillus gasseri PA-3 (PA-3) is a bacterial strain with a strong ability to degrade purine nucleosides. We previously showed that PA-3 incorporates purines in vitro and that oral administration of PA-3 and purines to rats attenuated their absorption of purines. It remains unclear whether these effects of PA-3 depend on bacterial strains. This study therefore compared the abilities of PA-3 and another bacterial strain of L. gasseri, OLL2996, which has shown decreased ability to degrade purine nucleosides in vitro, to incorporate purine nucleosides and to inhibit the absorption of purines fed to rats. Each bacterial strain was incubated in the presence of 14C-adenosine or 14C-inosine and the incorporation of each purine was evaluated by measuring their radioactivity. In vivo, rats were fed 14C-labeled purines along with PA-3 or OLL2996 and the absorption of these 14C-labeled purines was evaluated by analyzing radioactivity of blood samples. PA-3 incorporated about twice as much 14C-adenosine and 14C-inosine as OLL2996. The elevation of radioactivity levels in blood was 10-20% lower in rats treated with PA-3 than in control rats, after feeding with both 14C-adenosine and 14C-inosine as purines. In contrast, treatment with OLL...Continue Reading

References

Mar 1, 1991·The American Journal of Clinical Nutrition·D R GarrelP Hamet
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Mar 12, 2004·The New England Journal of Medicine·Hyon K ChoiGary Curhan
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Dec 3, 2011·Nucleosides, Nucleotides & Nucleic Acids·Hisashi Yamanaka, UNKNOWN Japanese Society of Gout and Nucleic Acid Metabolism

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Citations

Sep 29, 2019·Journal of Physics. Condensed Matter : an Institute of Physics Journal·Sudip PalSang-Wook Cheong
Jan 1, 2020·Food Science & Nutrition·Shasha XiangYuewen Chen

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