Lactobacillus johnsonii ameliorates intestinal, extra-intestinal and systemic pro-inflammatory immune responses following murine Campylobacter jejuni infection

Scientific Reports
S BereswillM M Heimesaat

Abstract

Campylobacter jejuni infections are progressively increasing worldwide. Probiotic treatment might open novel therapeutic or even prophylactic approaches to combat campylobacteriosis. In the present study secondary abiotic mice were generated by broad-spectrum antibiotic treatment and perorally reassociated with a commensal murine Lactobacillus johnsonii strain either 14 days before (i.e. prophylactic regimen) or 7 days after (i.e. therapeutic regimen) peroral C. jejuni strain 81-176 infection. Following peroral reassociation both C. jejuni and L. johnsonii were able to stably colonize the murine intestinal tract. Neither therapeutic nor prophylactic L. johnsonii application, however, could decrease intestinal C. jejuni burdens. Notably, C. jejuni induced colonic apoptosis could be ameliorated by prophylactic L. johnsonii treatment, whereas co-administration of L. johnsonii impacted adaptive (i.e. T and B lymphocytes, regulatory T cells), but not innate (i.e. macrophages and monocytes) immune cell responses in the intestinal tract. Strikingly, C. jejuni induced intestinal, extra-intestinal and systemic secretion of pro-inflammatory mediators (such as IL-6, MCP-1, TNF and nitric oxide) could be alleviated by peroral L. johnsonii ...Continue Reading

References

Oct 1, 1989·Journal of Clinical Microbiology·S J BhatiaA P Mehta
Feb 7, 2001·The American Journal of Clinical Nutrition·E IsolauriS Salminen
Jan 5, 2002·Contributions to Microbiology·M Kist, S Bereswill
Feb 18, 2003·Journal of Applied Microbiology·M F FernándezC Barbés
Sep 16, 2003·Journal of Medical Microbiology·Yuan-Kun LeeSeppo Salminen
Nov 23, 2005·Journal of Food Protection·Wu DingMansel W Griffiths
Dec 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Markus M HeimesaatOliver Liesenfeld
May 17, 2007·International Journal of Experimental Pathology·J MarcinkiewiczA Chmielarczyk
Aug 19, 2007·Nature Reviews. Microbiology·Kathryn T YoungVictor J Dirita
Aug 19, 2008·Trends in Microbiology·Patricia Guerry, Christine M Szymanski
Aug 21, 2008·Journal of Applied Microbiology·E D van AsseltM J Nauta
Dec 9, 2008·International Journal of Systematic and Evolutionary Microbiology·Marcus J ClaessonPaul W O'Toole
Aug 12, 2009·International Journal of Medical Microbiology : IJMM·Javid I DastiUwe Gross
Jun 29, 2010·International Journal of Food Microbiology·Jonathan A LaneRita M Hickey
Apr 25, 2012·PloS One·Marina L Ritchie, Tamara N Romanuk
Dec 11, 2013·Clinical & Developmental Immunology·Wycliffe Omurwa MasantaAndreas E Zautner
Jul 30, 2014·Nature Reviews. Neurology·Benjamin R WakerleyUNKNOWN GBS Classification Group
Oct 27, 2015·European Journal of Microbiology & Immunology·Marie E AlutisMarkus M Heimesaat
Jun 18, 2016·Genome Announcements·Xiaolin WuYanbo Sun

❮ Previous
Next ❯

Citations

Jan 8, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Bing XiaYaohong Zhu
Feb 23, 2020·Scientific Reports·Soraya MousaviMarkus M Heimesaat
Aug 27, 2021·Cellular and Molecular Gastroenterology and Hepatology·Joonyong LeeGuoli Dai

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies
Assay

Software Mentioned

GraphPad Prism

Related Concepts

Related Feeds

Campylobacteriosis (ASM)

Campylobacteriosis is caused by the bacteria Campylobacter jejuni and is a common cause of gastroenteritis in humans. Discover the latest research on Campylobacteriosis here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Campylobacteriosis

Campylobacteriosis is caused by the bacteria Campylobacter jejuni and is a common cause of gastroenteritis in humans. Discover the latest research on Campylobacteriosis here.