Lactobacillus Mucosal Vaccine Vectors: Immune Responses against Bacterial and Viral Antigens

MSphere
Jonathan S LeCureux, Gregg A Dean

Abstract

Lactic acid bacteria (LAB) have been utilized since the 1990s for therapeutic heterologous gene expression. The ability of LAB to elicit an immune response against expressed foreign antigens has led to their exploration as potential mucosal vaccine candidates. LAB vaccine vectors offer many attractive advantages: simple, noninvasive administration (usually oral or intranasal), the acceptance and stability of genetic modifications, relatively low cost, and the highest level of safety possible. Experimentation using LAB of the genus Lactobacillus has become popular in recent years due to their ability to elicit strong systemic and mucosal immune responses. This article reviews Lactobacillus vaccine constructs, including Lactobacillus species, antigen expression, model organisms, and in vivo immune responses, with a primary focus on viral and bacterial antigens.

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Citations

Oct 19, 2019·Vaccines·Allison C Vilander, Gregg A Dean
Jun 9, 2019·Applied Microbiology and Biotechnology·Keita TakahashiNaoki Inoue
Oct 20, 2018·Frontiers in Microbiology·Courtney Klotz, Rodolphe Barrangou
Oct 13, 2020·Frontiers in Microbiology·Viviane Lima BatistaMariana Martins Drumond
Mar 27, 2021·Probiotics and Antimicrobial Proteins·Shima Moradi-KalbolandiLeila Farahmand
Apr 7, 2021·Critical Reviews in Microbiology·Tejinder Pal Singh, Basavaprabhu Haranahalli Natraj
May 9, 2021·Acta Biochimica Et Biophysica Sinica·Seria Masole ShonyelaChunfeng Wang
Mar 21, 2021·Applied and Environmental Microbiology·Ben VezinaRobert J Moore
Jul 20, 2021·Advanced Drug Delivery Reviews·Chao PanHeng-Liang Wang

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Methods Mentioned

BETA
enzyme-linked immunosorbent spot

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