Lactobacillus paracasei PS23 Delays Progression of Age-Related Cognitive Decline in Senescence Accelerated Mouse Prone 8 (SAMP8) Mice

Nutrients
Shih-Yi HuangHui-Yu Huang

Abstract

Probiotic supplements are potential therapeutic agents for age-related disorders due to their antioxidant and anti-inflammatory properties. However, the effect of probiotics on age-related brain dysfunction remains unclear. To investigate the effects of Lactobacillus paracasei PS23 (LPPS23) on the progression of age-related cognitive decline, male and female senescence-accelerated mouse prone 8 (SAMP8) mice were divided into two groups (n = 6 each): the control and PS23 groups. From the age of 16 weeks, these groups were given saline and LPPS23, respectively, because SAMP8 mice start aging rapidly after four months of age. After 12 weeks of treatment, we evaluated the effect of LPPS23 by analyzing their appearance, behavior, neural monoamines, anti-oxidative enzymes, and inflammatory cytokines. The PS23 group showed lower scores of senescence and less serious anxiety-like behaviors and memory impairment compared to the control group. The control mice also showed lower levels of neural monoamines in the striatum, hippocampus, and serum. Moreover, LPPS23 induced the anti-oxidative enzymes superoxide dismutase (SOD) and glutathione peroxidase (GPx). Higher levels of tumor necrosis factor (TNF)-α and monocyte chemotactic protein-1 ...Continue Reading

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Citations

Feb 6, 2020·Frontiers in Neuroscience·Shin Jie YongWei Ling Lim
Jun 12, 2020·Neuroscience and Biobehavioral Reviews·Golnaz Tabibnia
Oct 19, 2019·Medical Hypotheses·Alejandra Romo-Araiza, Antonio Ibarra
Feb 2, 2021·Bioscience of Microbiota, Food and Health·Ying-Chieh TsaiYuan-Kun Lee
May 5, 2021·The International Journal of Neuroscience·LongQing ZhangXueBi Tian
Nov 13, 2021·Journal of Cachexia, Sarcopenia and Muscle·Li-Han ChenHui-Yu Huang
Nov 18, 2021·Journal of the Science of Food and Agriculture·Jianjun YangJunhua Jin

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Datasets Mentioned

BETA
DSM
32322

Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA

Software Mentioned

Ethovision
Noldus

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