Lactobacillus plantarum C29-Fermented Soybean (DW2009) Alleviates Memory Impairment in 5XFAD Transgenic Mice by Regulating Microglia Activation and Gut Microbiota Composition.

Molecular Nutrition & Food Research
Hae-Ji LeeDong-Hyun Kim

Abstract

The study aims to determine whether Lactobacillus plantarum C29-fermented defatted soybean (FDS, DW2009) can attenuate memory impairment in 5XFAD transgenic (Tg) mice. Oral administration of FDS or C29 increases cognitive function in Tg mice in passive avoidance, Y-maze, novel object recognition, and Morris water maze tasks. FDS or C29 treatment significantly suppresses amyloid-β, β/γ-secretases, caspase-3 expression, and NF-κB activation, and activates microglia and apoptotic neuron cell populations, and increases BDNF expression in the brain. FDS or C29 treatment suppresses blood and fecal lipopolysaccharide levels and Enterobacteriaceae population and increases lactobacilli/bifidobacteria populations. FDS and C29 alleviates the decrease in cognitive function and inhibited amyloid-β expression in Tg mice by regulating microglia activation and gut microbiota composition.

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Citations

Aug 25, 2020·Mediators of Inflammation·Kanglan LiBin Zhao
Oct 31, 2019·Journal of Cellular Physiology·Shouchao WeiZhiyou Cai
Jun 12, 2021·Frontiers in Immunology·Marcela Davoli-FerreiraKathy D McCoy
Oct 2, 2021·Applied Microbiology and Biotechnology·Hong-Fang Ji, Liang Shen

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