Lactobacillus plantarum HNU082-derived improvements in the intestinal microbiome prevent the development of hyperlipidaemia

Food & Function
Yuyu ShaoJiachao Zhang

Abstract

Restricted by research techniques, the probiotic-derived changes in the microbiome and microbial metabolites correlated with the potential prevention of hyperlipidaemia have remained undiscovered. In the present research, a metagenomic approach was applied to describe Lactobacillus plantarum HNU082 consumption-derived changes in the intestinal microbiome and their correlation with the occurrence and development of hyperlipidaemia. Principal coordinate analysis based on UniFrac distances indicated that the intestinal microbiota was profoundly altered in the hyperlipidaemia group, and probiotic consumption regulated the bias in the intestinal microbial structure in hyperlipidaemia. Bifidobacterium, Lactobacillus, Akkermansia and Faecalibacterium were significantly increased in the probiotic group, and the genera Clostridium, Natranaerovirga and Odoribacter were significantly increased in the hyperlipidaemia group. Further analysis based on metabolic pathways revealed that pyruvate metabolism, glycerolipid metabolism, propanoate metabolism, and fatty acid biosynthesis were enriched in the probiotic and control groups. In contrast, the pathways of secondary bile acid and lipopolysaccharide biosynthesis were enriched in the hyperlip...Continue Reading

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Citations

Sep 5, 2018·Frontiers in Microbiology·Jia XueYuyu Shao
Jan 28, 2021·Animal Microbiome·Daniela RosadoRaquel Xavier
Mar 31, 2021·Bioscience, Biotechnology, and Biochemistry·Chang WangXue-Gang Luo

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Datasets Mentioned

BETA
PRJCA000348
PRJNA379198

Methods Mentioned

BETA
phosphotransferase
PCR
Fluorescence

Software Mentioned

ade4
PICRUSt
QIIME
Cytoscape
PICRUSt ( Phylogenetic Investigation Communities
IDBA

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