Lactobacillus plantarum NCU116 Attenuates Cyclophosphamide-Induced Immunosuppression and Regulates Th17/Treg Cell Immune Responses in Mice

Journal of Agricultural and Food Chemistry
Junhua XieMingyong Xie

Abstract

The balance of T helper cells 17 (Th17)/regulatory T cells (Treg) plays a key role in maintaining a normal immune response. It is well-known that cyclophosphamide (CTX) applied at high dose often damages the immune system by inhibiting immune cell proliferation. In this study, the immunomodulating effects of Lactobacillus plantarum NCU116 in CTX-induced immunosuppression mice were investigated. Results showed that the levels of cytokines interleukin (IL)-17 and IL-21 were significantly increased after 10 days of treatment with a high dose of NCU116 (46.92 ± 4.28 and 119.92 ± 10.89, respectively) compared with the model group (36.20 ± 2.63, 61.00 ± 6.92, respectively), and the levels of cytokines IL-23 and TGF-β3 of the three NCU116 treatment groups were significantly higher than that of the model group (90.48 ± 6.33 and 140.45 ± 14.30, respectively) (p < 0.05) and close to 62 and 69% of the normal group's level (140.98 ± 14.74 and 266.95 ± 23.11, respectively) at 10 days. The bacterium was also found to increase the expression levels of Th17 immune response and Treg immune response specific transcription factors RORγt and Foxp3. In addition, the bacterium significantly increased the number of CD4(+)T cells and dendrtic cells (D...Continue Reading

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Citations

Jan 26, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yalin ZhouXin Zhao
Jan 24, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Qian ZhangXiangliang Yang
May 31, 2019·Journal of Immunology Research·Wenjie ZengMingyi Zhao
Apr 1, 2021·Archives of Medical Research·Shilia Jacob KurianMahadev Rao

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