Lactobacillus plantarum reverse diabetes-induced Fmo3 and ICAM expression in mice through enteric dysbiosis-related c-Jun NH2-terminal kinase pathways

PloS One
Wen-Chung LiuLee-Wei Chen

Abstract

Diabetes mellitus (DM) is characterized by increased fatality associated with the atherogenetic process. Circulating trimethylamine-N-oxide (TMAO) levels are closely associated with atherosclerosis. The flavin mono-oxygenase family (Fmo) members oxidize trimethylamine (TMA) to TMAO. The effect and the regulatory mechanism of intestinal microflora on diabetes-induced Fmo3 and intercellular adhesion molecule (ICAM) expression were examined in streptozotocin-induced diabetic mice (STZDM) and Akita mice (C57BL/6J-Ins2Akita). STZDM-JNK1-/- and Ins2Akita-JNK1-/- mice were produced and used to study the role of pJNK in the regulatory mechanisms. Diabetic mice exhibited decreased Lactobacilli growth and reactive oxygen species (ROS) production in the intestinal mucosa; increased levels of pJNK and iNOS proteins in the intestinal mucosa; increased levels of serum nitrate, IL-1β, and TNF-α expression in Kupffer cells; increased Fmo3 expression in the liver; and increased ICAM expression in the aorta. Reversal of diabetes-induced enteric dysbiosis by prebiotic (FOS) or probiotic (dead L. plantarum) treatment decreased diabetes-induced pJNK and iNOS expression in the intestine, Fmo3 expression in the liver, IL-1β expression in Kupffer cell...Continue Reading

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Citations

Feb 4, 2021·European Journal of Nutrition·Karen Salve Coutinho-WolinoMilena Barcza Stockler-Pinto
Jan 21, 2021·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Elena Barengolts, Emily Daviau Smith
Apr 27, 2021·Frontiers in Endocrinology·M Nazmul HudaBrian J Bennett
Jan 13, 2022·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Zaiwang LiGuangjun Xi

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Methods Mentioned

BETA
PCR
fluorescence spectroscopy
ELISA

Software Mentioned

QIIME ( Quantitative Insights Into Microbial Ecology )

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