Lactobacillus plantarum strain maintains growth of infant mice during chronic undernutrition

Science
Martin SchwarzerFrançois Leulier

Abstract

In most animal species, juvenile growth is marked by an exponential gain in body weight and size. Here we show that the microbiota of infant mice sustains both weight gain and longitudinal growth when mice are fed a standard laboratory mouse diet or a nutritionally depleted diet. We found that the intestinal microbiota interacts with the somatotropic hormone axis to drive systemic growth. Using monocolonized mouse models, we showed that selected lactobacilli promoted juvenile growth in a strain-dependent manner that recapitulated the microbiota's effect on growth and the somatotropic axis. These findings show that the host's microbiota supports juvenile growth. Moreover, we discovered that lactobacilli strains buffered the adverse effects of chronic undernutrition on the postnatal growth of germ-free mice.

References

Feb 1, 1994·Endocrine Reviews·J P ThissenL E Underwood
Mar 1, 1997·Cytokine & Growth Factor Reviews·D R Clemmons
Jul 8, 1997·Proceedings of the National Academy of Sciences of the United States of America·G B UdyH W Davey
Jun 6, 1998·Cellular and Molecular Life Sciences : CMLS·R Hakenbeck, J Coyette
Oct 20, 1999·Domestic Animal Endocrinology·B H Breier
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Jul 27, 2002·Domestic Animal Endocrinology·R RenavilleD Portetelle
Oct 3, 2003·Cellular and Molecular Life Sciences : CMLS·K Sugaya
Feb 19, 2005·Cellular and Molecular Life Sciences : CMLS·G MeyerE L Feldman
Feb 8, 2006·Journal of Molecular Endocrinology·M J WatersR J Brown
Nov 8, 2007·The Journal of Clinical Endocrinology and Metabolism·Solomon A Kaplan, Pinchas Cohen
Nov 27, 2008·Proceedings of the National Academy of Sciences of the United States of America·Elias StratikopoulosArgiris Efstratiadis
Jul 11, 2009·Endocrine Reviews·Claes OhlssonJohan Svensson
Sep 3, 2011·Lancet·Kazuomi KarioKenji Shibuya
Mar 13, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Klara SjögrenClaes Ohlsson
Apr 17, 2012·Cell·Mathieu Laplante, David M Sabatini
Aug 30, 2012·Nature Methods·Caroline A SchneiderKevin W Eliceiri
Feb 1, 2013·Science·Michelle I SmithJeffrey I Gordon
Mar 20, 2013·Cellular and Molecular Life Sciences : CMLS·Seogang Hyun
Mar 22, 2013·Cellular and Molecular Life Sciences : CMLS·Francesca TurroniDouwe van Sinderen
Jun 12, 2013·Lancet·Robert E BlackUNKNOWN Maternal and Child Nutrition Study Group
Aug 27, 2013·Biochemical and Biophysical Research Communications·Shu-Cheng YinZe-Zhang Tao
Dec 24, 2013·The Journal of Endocrinology·Pouneh K Fazeli, Anne Klibanski
Jul 23, 2014·Lancet·Ann Danaiya Usher
Sep 5, 2014·Microbial Cell Factories·Renata C Matos, François Leulier

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Citations

Mar 1, 2016·Nature Reviews. Microbiology·Andrea Du Toit
Apr 14, 2016·Nature·Derrick M Chu, Kjersti M Aagaard
Jun 9, 2016·BioResearch Open Access·Walter H MoosKosta Steliou
Jul 8, 2016·Nature·Mark R CharbonneauJeffrey I Gordon
Oct 8, 2016·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Briony E Forbes
Oct 22, 2016·Frontiers in Physiology·José L de Brito AlvesLuciano Pirola
Nov 9, 2016·Proceedings of the National Academy of Sciences of the United States of America·Jing YanJulia F Charles
Dec 23, 2016·Médecine sciences : M/S·Aline StedmanPhilippe J Sansonetti
Mar 9, 2017·Cell Metabolism·Niv ZmoraEran Elinav
Mar 1, 2017·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Jason D GussChristopher J Hernandez
Apr 26, 2017·PLoS Biology·Ricardo Leitão-GonçalvesCarlos Ribeiro
Apr 20, 2017·Proceedings of the National Academy of Sciences of the United States of America·Hao ZhengNancy A Moran
Jul 1, 2017·Future Microbiology·Andrew S NeishDavid S Stephens
Jun 18, 2017·Current Osteoporosis Reports·Jing Yan, Julia F Charles
Oct 19, 2017·Journal of Pediatric Gastroenterology and Nutrition·Paula Smith-BrownPeter S W Davies
Dec 8, 2017·Calcified Tissue International·Martin SchwarzerFrançois Leulier
Oct 2, 2017·Calcified Tissue International·P D'Amelio, F Sassi
Oct 29, 2017·Calcified Tissue International·Claes Ohlsson, Klara Sjögren
Feb 18, 2018·Calcified Tissue International·Laura R McCabe, Narayanan Parameswaran
Jan 25, 2018·Calcified Tissue International·Jing Yan, Julia F Charles
Aug 30, 2017·Cold Spring Harbor Perspectives in Medicine·Roberto Pacifici
Feb 13, 2018·Current Opinion in Clinical Nutrition and Metabolic Care·Martin Schwarzer
Oct 12, 2017·Calcified Tissue International·Emory Hsu, Roberto Pacifici
Sep 30, 2017·Gut Microbes·Jing YanJulia F Charles
Nov 5, 2017·Current Rheumatology Reports·Christopher J Hernandez
Jan 6, 2018·Nature Communications·Sébastien LucasMario M Zaiss
Jun 26, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yoko UchidaManabu Morita
May 18, 2018·International Journal of Food Sciences and Nutrition·Takashi KudaBon Kimura
Aug 1, 2018·International Journal of Molecular Sciences·Xiaoyong ChenZhennai Yang
Aug 5, 2017·Clinical Microbiology Reviews·Marwa K IbrahimPeter C Melby
Oct 26, 2018·Nature·Catherine E SchretterSarkis K Mazmanian

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