Lactobacillus plantarum ZJ316 Attenuates Helicobacter pylori-Induced Gastritis in C57BL/6 Mice.

Journal of Agricultural and Food Chemistry
Qingqing ZhouQing Gu

Abstract

Helicobacter pylori is a highly prevalent human-specific pathogen that causes various gastric diseases. In the present study, Lactobacillus plantarum ZJ316, which could survive well in simulated gastrointestinal conditions, was found to have significant anti-H. pylori ability. Animal assays revealed that L. plantarum ZJ316 had preventive and therapeutic effects on H. pylori-induced gastritis. L. plantarum ZJ316 significantly decreased interferon γ (IFN-γ) and interleukin 6 (IL-6) levels, increased the IL-10 level, and repaired mucosal damage. Moreover, 16S rRNA gene sequencing revealed that the relative abundance of H. pylori could be significantly reduced by L. plantarum ZJ316 administration. Members of the families Dehalobacteriaceae and Geodermatophilaceae were more prevalent in the prevention group, while Lactobacillaceae and Actinomycetaceae were more prevalent in the treatment group. These results indicate that L. plantarum ZJ316 serves as a potential candidate for the prevention and treatment of H. pylori-induced gastritis by regulating the gastric microbiota and reducing mucosal inflammation.

References

Oct 1, 1989·Journal of Clinical Microbiology·S J BhatiaA P Mehta
May 29, 1998·Infection and Immunity·M WilsonB Henderson
Dec 16, 2000·Current Microbiology·G L LorcaA Ljungh
Feb 13, 2001·Infection and Immunity·K StinglK Altendorf
May 1, 2001·The Journal of Antimicrobial Chemotherapy·I SakamotoY Koga
Aug 8, 2001·Alimentary Pharmacology & Therapeutics·R H HuntJ Q Huang
Feb 19, 2002·Alimentary Pharmacology & Therapeutics·M F Go
Feb 28, 2002·Alimentary Pharmacology & Therapeutics·P MalfertheinerUNKNOWN European Helicobacter Pylori Study Group (EHPSG)
Feb 8, 2003·British Journal of Biomedical Science·Virginia S Ocaña, María Elena Nader-Macías
May 20, 2003·Journal of Applied Microbiology·B KosS Matosić
Jul 16, 2003·Journal of Gastroenterology and Hepatology·Atsushi UshiyamaYasuhiro Koga
Oct 3, 2003·International Journal of Antimicrobial Agents·J M T Hamilton-Miller
Jan 9, 2004·Applied and Environmental Microbiology·D SgourasA Mentis
Jun 9, 2004·Applied and Environmental Microbiology·Gerald W Tannock
Apr 26, 2005·International Journal of Antimicrobial Agents·M C ColladoY Sanz
Oct 28, 2006·The Lancet Infectious Diseases·Monique M GerritsJohannes G Kusters
Jan 4, 2007·The Journal of Clinical Investigation·James G Fox, Timothy C Wang
Feb 22, 2007·The Journal of Nutrition·Drahoslava Lesbros-PantoflickovaAndré L Blum
Feb 12, 2008·The Journal of Antimicrobial Chemotherapy·Kieran A RyanPaul W O'Toole
Jun 27, 2008·Clinical and Vaccine Immunology : CVI·E MyllyluomaE Kankuri
Sep 9, 2010·Proceedings of the National Academy of Sciences of the United States of America·Peter van BaarlenMichiel Kleerebezem
Nov 22, 2011·Journal of Gastroenterology and Hepatology·Ryuzo DeguchiAtsushi Takagi
Feb 22, 2012·Nature Reviews. Gastroenterology & Hepatology·Indrani MukhopadhyaGeorgina L Hold
Aug 25, 2012·Frontiers in Cellular and Infection Microbiology·Samuel L PalframanKipros Gabriel
Feb 14, 2013·Irish Journal of Medical Science·H El-AdawiM Hussein
Mar 22, 2013·Genome Announcements·Xuan LiYizhen Zhao
Jun 13, 2013·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Ami PatelJ B Prajapati
Nov 2, 2013·Internal and Emergency Medicine·Maria Pina DoreDavid Yates Graham
Sep 5, 2014·Microbial Cell Factories·Marijke E Segers, Sarah Lebeer
Oct 23, 2016·Lancet·Jyh-Ming LiouUNKNOWN Taiwan Gastrointestinal Disease and Helicobacter Consortium
Mar 10, 2017·Cellular and Molecular Gastroenterology and Hepatology·Steven F Moss

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