Lactobacillus reuteri maintains intestinal epithelial regeneration and repairs damaged intestinal mucosa.

Gut Microbes
Haiqin WuQinghua Yu

Abstract

Little is known about the regulatory effect of microbiota on the proliferation and regeneration of ISCs. Here, we found that L. reuteri stimulated the proliferation of intestinal epithelia by increasing the expression of R-spondins and thus activating the Wnt/β-catenin pathway. The proliferation-stimulating effect of Lactobacillus on repair is further enhanced under TNF -induced intestinal mucosal damage, and the number of Lgr5+ cells is maintained. Moreover, compared to the effects of C. rodentium on the induction of intestinal inflammation and crypt hyperplasia in mice, L. reuteri protected the intestinal mucosal barrier integrity by moderately modulating the Wnt/β-catenin signaling pathway to avoid overactivation. L. reuteri had the ability to maintain the number of Lgr5+ cells and stimulate intestinal epithelial proliferation to repair epithelial damage and reduce proinflammatory cytokine secretion in the intestine and the LPS concentration in serum. Moreover, activation of the Wnt/β-catenin pathway also induced differentiation toward Paneth cells and increased antimicrobial peptide expression to inhibit C. rodentium colonization. The protective effect of Lactobacillus against C. rodentium infection disappeared upon applica...Continue Reading

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Citations

Nov 6, 2020·Current Opinion in Gastroenterology·Rishu Dheer, Vincent B Young
Mar 17, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Hasan AlghetaaPrakash Nagarkatti
Apr 3, 2021·Cell Host & Microbe·Gaofeng WangLuis A Garza

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Datasets Mentioned

BETA
MF850249

Methods Mentioned

BETA
light microscopy
confocal microscopy
ELISA
nuclear translocation

Software Mentioned

ImageJ
Pro Plus
Image

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