Lactobacillus rhamnosus CRL1505 nasal administration improves recovery of T-cell mediated immunity against pneumococcal infection in malnourished mice

Beneficial Microbes
N BarbieriS Alvarez

Abstract

Immunobiotic lactic acid bacteria have become an interesting alternative for the prevention of respiratory infections. Previously, we demonstrated that the nasal administration of Lactobacillus rhamnosus CRL1505, during repletion of malnourished mice, resulted in diminished susceptibility to the challenge with the respiratory pathogen Streptococcus pneumoniae. Considering the known alterations induced by malnutrition on T lymphocytes and the importance of this cell population on the protection against respiratory pathogens, we aimed to study the effect of L. rhamnosus CRL1505 nasal administration on the recovery of T cell-mediated defences against pneumococcal infection in malnourished mice under nutritional recovery. Malnourished mice received a balanced conventional diet (BCD) for seven days or BCD for seven days with nasal L. rhamnosus CRL1505 supplementation during last two days of the treatment. After the treatments mice were infected with S. pneumoniae. Flow cytometry studies were carried out in bone marrow, thymus, spleen and lung to study T cells, and Th1/Th2 cytokine profiles were determined in broncho-alveolar lavages and serum. The administration of CRL1505 strain to malnourished mice under recovery reduced quantitat...Continue Reading

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Citations

Aug 14, 2020·International Journal of Food Sciences and Nutrition·Benedetta BottariErasmo Neviani
Aug 20, 2020·Applied Microbiology and Biotechnology·Aravind SundararamanPrakash M Halami
Nov 17, 2020·Frontiers in Bioengineering and Biotechnology·Martina OrianoPaola Petrini
Sep 12, 2021·Gastroenterology·Harry Cheuk-Hay LauJun Yu

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