Lactobacillus rhamnosus GG defense against Salmonella enterica serovar Typhimurium infection through modulation of M1 macrophage polarization.

Microbial Pathogenesis
Bingjie DuanChunfeng Wang

Abstract

Lactobacillus rhamnosus GG (LGG), a model probiotic strain, plays an important role in immune regulatory activity to prevent and treat intestinal inflammation or diarrhea. However, the effect of the immune modulation of LGG on macrophages to prevent Salmonella infection has not been thoroughly studied. In this study, C57BL/6 mice were pre-administered LGG for 7 days continuously, and then infected with Salmonella enterica subsp. enterica serovar Typhimurium (S. Typhimurium). The results of the in vivo study indicated that LGG could reduce body weight loss, death rate and intestinal inflammatory response caused by S. Typhimurium. LGG also limited S. Typhimurium dissemination to liver and spleen, and thereby protected against infection. In vitro study, we observed that LGG enhanced the phagocytic and bactericidal ability of macrophages and upregulated M1 macrophage characters (e.g. iNOS, NO and IL-12) against S. Typhimurium. In addition, LGG also elevated IL-10 secretion, which was helpful to ameliorate intestinal inflammatory injury caused by S. Typhimurium. In conclusion, LGG could modulate M1 macrophage polarization and offer protective effects against S. Typhimurium infection.

References

Apr 26, 2002·Journal of Applied Microbiology·M A EhrmannR F Vogel
Sep 17, 2004·Nature Reviews. Microbiology·Denise M MonackStanley Falkow
Sep 21, 2004·Nature Reviews. Microbiology·Ferric C Fang
Aug 9, 2005·Gastroenterology Clinics of North America·Shira DoronSherwood L Gorbach
Dec 3, 2005·Nature Reviews. Immunology·Siamon Gordon, Philip R Taylor
Jan 18, 2007·World Journal of Gastroenterology : WJG·Benoit FoligneBruno Pot
Nov 20, 2008·Current Protocols in Immunology·Xia ZhangDavid M Mosser
Jun 1, 2010·Immunity·Siamon Gordon, Fernando O Martinez
Feb 26, 2011·Immunological Reviews·Gordon DouganPietro Mastroeni
Jun 16, 2012·Nature Reviews. Immunology·David M Underhill, Helen S Goodridge
Jul 11, 2012·Journal of Cellular Physiology·Guangwei Liu, Hui Yang
Oct 30, 2012·Cell·Ramkumar MathurSankar Ghosh
Feb 11, 2014·American Journal of Physiology. Lung Cellular and Molecular Physiology·Neil R AggarwalFranco R D'Alessio
Sep 5, 2014·Microbial Cell Factories·Marijke E Segers, Sarah Lebeer
Nov 5, 2014·Frontiers in Immunology·Paola Italiani, Diana Boraschi
Dec 17, 2014·Frontiers in Immunology·Nan WangKe Zen
Mar 10, 2015·Nature Reviews. Microbiology·A Marijke Keestra-GounderAndreas J Bäumler
Sep 16, 2015·International Journal of Medical Microbiology : IJMM·Antonietta RizzoNazario Bevilacqua
Nov 26, 2015·Journal of Nutritional Science and Vitaminology·Hye-Ji Kang, Sin-Hyeog Im
Dec 19, 2015·Research in Veterinary Science·W M Quinteiro-FilhoS Sharif
Feb 18, 2016·Cellular Microbiology·Lars FrankenChristian Kurts
Apr 7, 2016·Best Practice & Research. Clinical Gastroenterology·Gregor Reid
Aug 2, 2017·Journal of Immunology Research·L M Rocha-RamírezC Eslava

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.