Lactobacillus spp. reduces morphological changes and oxidative stress induced by deoxynivalenol on the intestine and liver of broilers

Toxicon : Official Journal of the International Society on Toxinology
Marielen de SouzaAna Paula F R L Bracarense

Abstract

The mycotoxin deoxynivalenol (DON) contaminates animal feed worldwide, frequently resulting in poor performance and economic losses. Data concerning the effects on poultry health or focusing on intestinal toxicity or the response to oxidative stress are scarce. Also, there is a need for strategies to mitigate the negative effects of DON. This study aimed to investigate the effects of Lactobacillus spp. treatments on the intestine, liver and kidney of poultry fed a DON-contaminated diet. To achieve this aim, histological, morphometrical and histochemical assays were performed. The oxidative stress response was also analyzed by the tests: reduced glutathione, ferric reducing ability, reducing of 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid), nitro blue tetrazolium detection of superoxide anion, and thiobarbituric acid reactive substances. One-day-old broilers chickens (n 50) were submitted to the following treatments: control, DON (19.3 mg kg-1), viable Lactobacillus spp. + DON (VL + DON), heat-inactivated Lactobacillus spp. + DON (HIL + DON), Lactobacillus spp. culture supernatant + DON (LCS + DON). The animals received the contaminated diet for seven days. DON increased the intestinal and liver lesion score, while th...Continue Reading

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Citations

Apr 27, 2021·Molecular Nutrition & Food Research·Jinxia LiuBolin Zhang
Jun 3, 2021·International Journal of Molecular Sciences·Tereza KubasovaIvan Rychlik
Jul 5, 2021·Toxicon : Official Journal of the International Society on Toxinology·Vinicius DuarteCarlos Augusto Mallmann
Aug 5, 2021·Critical Reviews in Food Science and Nutrition·Haonan RuanMeihua Yang
Aug 18, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yongsong BaiAnshan Shan
Nov 9, 2021·In Vitro Cellular & Developmental Biology. Animal·Marcela Bortoletto CerezettiFábio Morotti

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